WormBase Tree Display for Gene: WBGene00001194
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WBGene00001194 | SMap | S_parent | Sequence | C04A2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | egl | ||||||
Reference_allele | WBVar00089296 | ||||||
Allele (248) | |||||||
Legacy_information | n170 : variable bloating moderate to severe Type E; possibly abnormal vulva; males very abnormal : reduced rays short spicules swollen bursa hermaphroditic tail spike. ES2 (adult). ES3 (adult male). ME0. NA1. | ||||||
See also e2394, n170 | |||||||
[C.elegansII] n170 : variable bloating, moderate to severe; variable drug response; possibly abnormal vulva; Mig; males Lin, very abnormal : reduced rays, short spicules, swollen bursa, hermaphroditic tail spike. ES2 (adult). ES3 (adult male).ME0. OA1: e2394. [Trent et al. 1983; Desai et al. 1988; CZ; MT] | |||||||
Complementation_data | [Chisholm AD] complements let-263 | ||||||
Strain (13) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (41) | |||||||
Contained_in_operon | CEOP2739 | ||||||
Ortholog (36) | |||||||
Paralog | WBGene00003025 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Structured_description | Concise_description | egl-27 encodes, along with lin-40, one of two C. elegans homologs of human MTA1 (metastasis-associated protein), part of a nucleosome remodeling and histone deacetylation (NURD) complex; in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8; egl-27 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; EGL-27 acts downstream of DAF-2 and recognizes the GATA/DAE (DAF-16-associated element) promoter motif of DAF-16 target genes; together with DAF-16 it promotes developmental growth in response to DNA damage. | Paper_evidence | WBPaper00003578 | |||
WBPaper00005068 | |||||||
WBPaper00012788 | |||||||
WBPaper00012830 | |||||||
WBPaper00012882 | |||||||
WBPaper00012897 | |||||||
WBPaper00013003 | |||||||
WBPaper00040964 | |||||||
WBPaper00047070 | |||||||
Person_evidence | WBPerson4498 | ||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 28 Oct 2015 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and enzyme binding activity. Involved in several processes, including egg-laying behavior; hemidesmosome assembly; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including Y cell; intestinal cell; neurons; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Is an ortholog of human RERE (arginine-glutamic acid dipeptide repeats). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0060162 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3033) | ||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3033) | ||||
Molecular_info | Corresponding_CDS (18) | ||||||
Corresponding_CDS_history | C04A2.3:wp81 | ||||||
C04A2.3b:wp233 | |||||||
Corresponding_transcript (24) | |||||||
Other_sequence (23) | |||||||
Associated_feature (42) | |||||||
Gene_product_binds (1510) | |||||||
Transcription_factor | WBTranscriptionFactor000021 | ||||||
Experimental_info | RNAi_result (77) | ||||||
Expr_pattern (17) | |||||||
Drives_construct (10) | |||||||
Construct_product | WBCnstr00007732 | ||||||
WBCnstr00010198 | |||||||
WBCnstr00012481 | |||||||
WBCnstr00016564 | |||||||
WBCnstr00017088 | |||||||
WBCnstr00037037 | |||||||
Microarray_results (42) | |||||||
Expression_cluster (160) | |||||||
Interaction (170) | |||||||
Anatomy_function | WBbtf0744 | ||||||
Product_binds_matrix | WBPmat00005570 | ||||||
WBPmat00005580 | |||||||
WBProcess | WBbiopr:00000020 | ||||||
WBbiopr:00000024 | |||||||
WBbiopr:00000071 | |||||||
WBbiopr:00000072 | |||||||
Map_info | Map | II | Position | 0.116063 | Error | 0.000615 | |
Well_ordered | |||||||
Positive | Positive_clone | C04A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 735 | |||||
Multi_point | 631 | ||||||
1718 | |||||||
1719 | |||||||
2310 | |||||||
2311 | |||||||
Pos_neg_data | 6857 | ||||||
6858 | |||||||
Reference (85) | |||||||
Picture | WBPicture0000013092 | ||||||
Method | Gene |