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WormBase Tree Display for Gene: WBGene00000254

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Name Class

WBGene00000254SMapS_parentSequenceK04F10
IdentityVersion1
NameCGC_namebli-4Person_evidenceWBPerson261
Sequence_nameK04F10.4
Molecular_name (31)
Other_namelet-77
kpc-4
CELE_K04F10.4Accession_evidenceNDBBX284601
Public_namebli-4
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classbli
Reference_alleleWBVar00143617
Allele (169)
Legacy_informatione937 : adult blistered especially head. ES3 (old adult) ME1. NA1.
s90 : late larval lethal. NA1.
Late larval lethal
See also s90
[C.elegansII] e937 : adult blistered, especially head; penetrance 90%; unique Class I allele. ES3 (old adult) ME1. OA13: all other alleles result in late embryonic lethality, most are class II, fail to complemente937. e.g. h42, h199, h254, h1403. Also s90(pka let-77, class III allele, late larval lethal,complements e937 but not other alleles)Cloned: multiple alternatively spliced transcripts, encoding predicted endoproteases (KEX2/subtilisin class) with different C-termini,[Peters et al. 1991, Thacker et al. 1995, KR]
Complementation_data[Rose AM] complements bli-4(e937), does not complement lethal alleles of bli-4
Strain (496)
RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (36)
ParalogWBGene00000088Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001172Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002232Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017686Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionbli-4 encodes a variety of related subtilases (serine endoproteases of the KEX2/subtilisin class), with shared N-termini but varying C-termini, that are collectively required both for larval viability and for stable adhesion of the adult cuticle.Paper_evidenceWBPaper00001439
WBPaper00002160
WBPaper00023862
Curator_confirmedWBPerson567
Date_last_updated30 Jul 2004 00:00:00
Automated_descriptionPredicted to enable serine-type endopeptidase activity. Involved in several processes, including chemosensory behavior; collagen and cuticulin-based cuticle development; and positive regulation of synaptic assembly at neuromuscular junction. Located in nucleus. Expressed in head; hypodermis; ventral cord neurons; and vulva.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSK04F10.4a
K04F10.4b
K04F10.4c
K04F10.4d
K04F10.4e
K04F10.4f
K04F10.4g
K04F10.4h
K04F10.4i
K04F10.4j
Corresponding_CDS_historyK04F10.4e:wp250
Corresponding_transcript (11)
Other_sequence (63)
Associated_feature (36)
Experimental_infoRNAi_result (20)
Expr_patternExpr1543
Expr6325
Expr12812
Expr1013652
Expr1030164
Expr1153628
Expr2009630
Expr2027869
Drives_constructWBCnstr00002667
WBCnstr00010329
WBCnstr00037625
Construct_productWBCnstr00010329
WBCnstr00037625
Microarray_results (73)
Expression_cluster (145)
Interaction (73)
WBProcessWBbiopr:00000124
Map_infoMapIPosition1.02135Error0.002014
Well_ordered
PositiveInside_rearrqDf16
nDp1
Positive_cloneK04F10Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrsDf4
Mapping_data2_point (11)
Multi_point (21)
Pos_neg_data (48)
Landmark_gene
Reference (85)
Remark[Rose AM] complex complementation pattern
kpc-4 was merged into this gene
MethodGene