WormBase Tree Display for Gene: WBGene00000222
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| WBGene00000222 | SMap | S_parent | Sequence | F45E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | atf-6 | Person_evidence | WBPerson531 | |||||
| Sequence_name | F45E6.2 | ||||||||
| Molecular_name | F45E6.2 | ||||||||
| F45E6.2.1 | |||||||||
| CE17828 | |||||||||
| Other_name | CELE_F45E6.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | atf-6 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | atf | ||||||||
| Allele (58) | |||||||||
| Strain | WBStrain00035282 | ||||||||
| WBStrain00035283 | |||||||||
| WBStrain00031485 | |||||||||
| Component_of_genotype | WBGenotype00000044 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Contained_in_operon | CEOPX108 | ||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00000793 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00002783 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016162 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor requiredfor the unfolded protein response (UPR) in the endoplasmic reticulum (ER);ATF6alpha is a transmembrane protein, with a bZIP transcription factordomain in its cytosolic amino terminus that is released and activated byproteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions aresynthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethalwith ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleavesATF-6; atf-6 regulates few genes that are transcriptionally induced byUPR, but regulates roughly one-quarter of genes that require UPRconstitutively; pdr-1 transcripts are strongly upregulated in aatf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) doublemutants have a grossly normal phenotype ; atf-6 is dispensable for properlocalization of GLR-1 glutamate receptors. | Paper_evidence | WBPaper00024285 | |||||
| WBPaper00026830 | |||||||||
| WBPaper00026844 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 04 Apr 2008 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in nucleus. Expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Is an ortholog of human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110009 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:791) | ||||
| Modifies_disease | DOID:12377 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000881 | ||||||||
| Molecular_info | Corresponding_CDS | F45E6.2 | |||||||
| Corresponding_transcript | F45E6.2.1 | ||||||||
| Associated_feature | WBsf648618 | ||||||||
| WBsf655219 | |||||||||
| WBsf663413 | |||||||||
| WBsf978510 | |||||||||
| WBsf982250 | |||||||||
| WBsf1007312 | |||||||||
| WBsf1024056 | |||||||||
| WBsf236494 | |||||||||
| WBsf236495 | |||||||||
| Transcription_factor | WBTranscriptionFactor000147 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Chronogram64 | ||||||||
| Chronogram276 | |||||||||
| Chronogram396 | |||||||||
| Expr7566 | |||||||||
| Expr11253 | |||||||||
| Expr1022678 | |||||||||
| Expr1030139 | |||||||||
| Expr1151258 | |||||||||
| Expr2009481 | |||||||||
| Expr2027718 | |||||||||
| Drives_construct | WBCnstr00001092 | ||||||||
| WBCnstr00001093 | |||||||||
| WBCnstr00012711 | |||||||||
| WBCnstr00018514 | |||||||||
| WBCnstr00037650 | |||||||||
| Construct_product | WBCnstr00037650 | ||||||||
| WBCnstr00038820 | |||||||||
| Regulate_expr_cluster | WBPaper00060224:atf-6(ok551)_downregulated | ||||||||
| WBPaper00060224:atf-6(ok551)_upregulated | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (126) | |||||||||
| Interaction (116) | |||||||||
| WBProcess | WBbiopr:00000046 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | X | Position | 7.11398 | Error | 0.001998 | |||
| Positive | Positive_clone | F45E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (59) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
