WormBase Tree Display for Disease_model_annotation: WBDOannot00000881
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| WBDOannot00000881 | Disease_term | DOID:12377 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Genotype | WBGenotype00000044 | |
| Asserted_gene | WBGene00004887 | ||
| Association_type | is_exacerbated_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_gene | WBGene00000222 | |
| Modifier_association_type | condition_exacerbated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00037843 | ||
| Disease_model_description | Spinal Muscular Atrophy (SMA) is a common, untreatable, and often fatal neuromuscular disease predominately caused by reduced Survival Motor Neuron (SMN) protein function; smn-1(ok355) worms have growth and neuromuscular defects; knockdown of atf-6 via RNAi enhances the growth defects of the smn-1 loss of function worms identifying it as a gene that modulates the neuropathology of smn-1. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 24 Feb 2021 00:00:00 |
