WormBase Tree Display for Gene: WBGene00000222
expand all nodes | collapse all nodes | view schema
WBGene00000222 | SMap | S_parent | Sequence | F45E6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name (5) | |||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | atf | ||||||||
Allele (58) | |||||||||
Strain | WBStrain00035282 | ||||||||
WBStrain00035283 | |||||||||
WBStrain00031485 | |||||||||
Component_of_genotype | WBGenotype00000044 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (26) | |||||||||
Contained_in_operon | CEOPX108 | ||||||||
Ortholog (29) | |||||||||
Paralog | WBGene00000793 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
WBGene00002783 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00016162 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor requiredfor the unfolded protein response (UPR) in the endoplasmic reticulum (ER);ATF6alpha is a transmembrane protein, with a bZIP transcription factordomain in its cytosolic amino terminus that is released and activated byproteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions aresynthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethalwith ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleavesATF-6; atf-6 regulates few genes that are transcriptionally induced byUPR, but regulates roughly one-quarter of genes that require UPRconstitutively; pdr-1 transcripts are strongly upregulated in aatf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) doublemutants have a grossly normal phenotype ; atf-6 is dispensable for properlocalization of GLR-1 glutamate receptors. | Paper_evidence | WBPaper00024285 | |||||
WBPaper00026830 | |||||||||
WBPaper00026844 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 04 Apr 2008 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in nucleus. Expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Is an ortholog of human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0110009 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:791) | ||||
Modifies_disease | DOID:12377 | ||||||||
Modifies_disease_in_annotation | WBDOannot00000881 | ||||||||
Molecular_info | Corresponding_CDS | F45E6.2 | |||||||
Corresponding_transcript | F45E6.2.1 | ||||||||
Associated_feature | WBsf648618 | ||||||||
WBsf655219 | |||||||||
WBsf663413 | |||||||||
WBsf978510 | |||||||||
WBsf982250 | |||||||||
WBsf1007312 | |||||||||
WBsf1024056 | |||||||||
WBsf236494 | |||||||||
WBsf236495 | |||||||||
Transcription_factor | WBTranscriptionFactor000147 | ||||||||
Experimental_info | RNAi_result (18) | ||||||||
Expr_pattern | Chronogram64 | ||||||||
Chronogram276 | |||||||||
Chronogram396 | |||||||||
Expr7566 | |||||||||
Expr11253 | |||||||||
Expr1022678 | |||||||||
Expr1030139 | |||||||||
Expr1151258 | |||||||||
Expr2009481 | |||||||||
Expr2027718 | |||||||||
Drives_construct (5) | |||||||||
Construct_product | WBCnstr00037650 | ||||||||
WBCnstr00038820 | |||||||||
Regulate_expr_cluster | WBPaper00060224:atf-6(ok551)_downregulated | ||||||||
WBPaper00060224:atf-6(ok551)_upregulated | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (126) | |||||||||
Interaction (116) | |||||||||
WBProcess | WBbiopr:00000046 | ||||||||
WBbiopr:00000079 | |||||||||
Map_info | Map | X | Position | 7.11398 | Error | 0.001998 | |||
Positive | Positive_clone | F45E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (59) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |