WormBase Tree Display for Gene: WBGene00006784
expand all nodes | collapse all nodes | view schema
WBGene00006784 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T21C12 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | unc-49 | Person_evidence | WBPerson261 | |||||
Sequence_name | T21C12.1 | ||||||||
Molecular_name (40) | |||||||||
Other_name | unc-49A | Accession_evidence | EMBL | AF151640 | |||||
unc-49B | Accession_evidence | EMBL | AF151641 | ||||||
unc-49C | Accession_evidence | EMBL | AF151644 | ||||||
CELE_T21C12.1 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | unc-49 | ||||||||
DB_info | Database | AceView | gene | 3L621 | |||||
WormQTL | gene | WBGene00006784 | |||||||
WormFlux | gene | WBGene00006784 | |||||||
NDB | locus_tag | CELE_T21C12.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006784|UniProtKB=G5ECD3 | |||||||
family | PTHR18945 | ||||||||
NCBI | gene | 176472 | |||||||
RefSeq | protein (13) | ||||||||
TrEMBL | UniProtAcc (13) | ||||||||
UniProt_GCRP | UniProtAcc | G5ECD3 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143164 | ||||||||
Allele (220) | |||||||||
Legacy_information | e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468). | ||||||||
See also e641, n1324 | |||||||||
[C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT] | |||||||||
Strain (14) | |||||||||
Component_of_genotype | WBGenotype00000119 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Ortholog (37) | |||||||||
Paralog (100) | |||||||||
Structured_description | Concise_description | unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. | Paper_evidence | WBPaper00003576 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 24 Aug 2007 00:00:00 | ||||||||
Automated_description | Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00060194 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 18 May 2022 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00001202 | ||||||||
WBDOannot00001203 | |||||||||
Molecular_info | Corresponding_CDS (13) | ||||||||
Corresponding_CDS_history | T21C12.1a:wp227 | ||||||||
T21C12.1a:wp239 | |||||||||
T21C12.1g:wp275 | |||||||||
Corresponding_transcript (14) | |||||||||
Other_sequence (51) | |||||||||
Associated_feature (25) | |||||||||
Experimental_info | RNAi_result | WBRNAi00090257 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00053708 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089728 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066348 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027895 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00000954 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00090099 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00018961 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089939 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00006214 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1283 | ||||||||
Expr15907 | |||||||||
Expr1027570 | |||||||||
Expr1032855 | |||||||||
Expr1157259 | |||||||||
Expr1200291 | |||||||||
Expr2017881 | |||||||||
Expr2036017 | |||||||||
Marker2 | |||||||||
Marker19 | |||||||||
Drives_construct (8) | |||||||||
Construct_product | WBCnstr00001627 | ||||||||
WBCnstr00006881 | |||||||||
WBCnstr00016180 | |||||||||
WBCnstr00019381 | |||||||||
WBCnstr00020010 | |||||||||
WBCnstr00020581 | |||||||||
WBCnstr00021428 | |||||||||
WBCnstr00034153 | |||||||||
Antibody | WBAntibody00000613 | ||||||||
WBAntibody00001987 | |||||||||
Microarray_results (88) | |||||||||
Expression_cluster (187) | |||||||||
Interaction (31) | |||||||||
WBProcess | WBbiopr:00000010 | ||||||||
Map_info | Map | III | Position | 3.35021 | Error | 0.089636 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf40 | |||||||
mT1 | |||||||||
Positive_clone | T21C12 | Person_evidence | WBPerson39 | ||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | 2_point | 73 | |||||||
86 | |||||||||
589 | |||||||||
3249 | |||||||||
Multi_point (55) | |||||||||
Pos_neg_data | 3242 | ||||||||
3250 | |||||||||
3251 | |||||||||
Reference | WBPaper00000031 | ||||||||
WBPaper00000608 | |||||||||
WBPaper00001345 | |||||||||
WBPaper00001473 | |||||||||
WBPaper00001687 | |||||||||
WBPaper00001759 | |||||||||
WBPaper00001780 | |||||||||
WBPaper00001861 | |||||||||
WBPaper00001920 | |||||||||
WBPaper00002272 | |||||||||
WBPaper00002297 | |||||||||
WBPaper00003024 | |||||||||
WBPaper00003576 | |||||||||
WBPaper00003746 | |||||||||
WBPaper00003781 | |||||||||
WBPaper00004146 | |||||||||
WBPaper00004217 | |||||||||
WBPaper00004257 | |||||||||
WBPaper00005092 | |||||||||
WBPaper00005274 | |||||||||
WBPaper00005543 | |||||||||
WBPaper00005785 | |||||||||
WBPaper00005798 | |||||||||
WBPaper00005799 | |||||||||
WBPaper00006103 | |||||||||
WBPaper00006172 | |||||||||
WBPaper00006173 | |||||||||
WBPaper00006402 | |||||||||
WBPaper00010938 | |||||||||
WBPaper00011509 | |||||||||
WBPaper00014017 | |||||||||
WBPaper00014249 | |||||||||
WBPaper00015297 | |||||||||
WBPaper00016817 | |||||||||
WBPaper00017129 | |||||||||
WBPaper00017309 | |||||||||
WBPaper00017332 | |||||||||
WBPaper00017387 | |||||||||
WBPaper00017967 | |||||||||
WBPaper00018015 | |||||||||
WBPaper00018310 | |||||||||
WBPaper00018559 | |||||||||
WBPaper00018906 | |||||||||
WBPaper00019199 | |||||||||
WBPaper00019357 | |||||||||
WBPaper00020952 | |||||||||
WBPaper00021100 | |||||||||
WBPaper00021652 | |||||||||
WBPaper00022200 | |||||||||
WBPaper00022393 | |||||||||
WBPaper00022453 | |||||||||
WBPaper00022718 | |||||||||
WBPaper00022822 | |||||||||
WBPaper00022978 | |||||||||
WBPaper00022998 | |||||||||
WBPaper00023616 | |||||||||
WBPaper00024317 | |||||||||
WBPaper00024523 | |||||||||
WBPaper00024530 | |||||||||
WBPaper00024533 | |||||||||
WBPaper00024794 | |||||||||
WBPaper00025006 | |||||||||
WBPaper00025245 | |||||||||
WBPaper00026361 | |||||||||
WBPaper00026385 | |||||||||
WBPaper00026679 | |||||||||
WBPaper00026711 | |||||||||
WBPaper00026870 | |||||||||
WBPaper00027091 | |||||||||
WBPaper00027175 | |||||||||
WBPaper00027250 | |||||||||
WBPaper00028525 | |||||||||
WBPaper00028820 | |||||||||
WBPaper00029175 | |||||||||
WBPaper00030873 | |||||||||
WBPaper00030968 | |||||||||
WBPaper00031010 | |||||||||
WBPaper00031038 | |||||||||
WBPaper00031546 | |||||||||
WBPaper00031872 | |||||||||
WBPaper00031996 | |||||||||
WBPaper00032190 | |||||||||
WBPaper00032252 | |||||||||
WBPaper00032789 | |||||||||
WBPaper00032818 | |||||||||
WBPaper00033002 | |||||||||
WBPaper00033406 | |||||||||
WBPaper00033499 | |||||||||
WBPaper00034209 | |||||||||
WBPaper00035082 | |||||||||
WBPaper00035198 | |||||||||
WBPaper00035247 | |||||||||
WBPaper00035980 | |||||||||
WBPaper00036006 | |||||||||
WBPaper00036766 | |||||||||
WBPaper00037168 | |||||||||
WBPaper00037312 | |||||||||
WBPaper00037326 | |||||||||
WBPaper00037333 | |||||||||
WBPaper00037336 | |||||||||
WBPaper00038249 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00039150 | |||||||||
WBPaper00039251 | |||||||||
WBPaper00040417 | |||||||||
WBPaper00041069 | |||||||||
WBPaper00041225 | |||||||||
WBPaper00042154 | |||||||||
WBPaper00042429 | |||||||||
WBPaper00042985 | |||||||||
WBPaper00045139 | |||||||||
WBPaper00045142 | |||||||||
WBPaper00045634 | |||||||||
WBPaper00046928 | |||||||||
WBPaper00048837 | |||||||||
WBPaper00049631 | |||||||||
WBPaper00050339 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00055158 | |||||||||
WBPaper00057011 | |||||||||
WBPaper00057202 | |||||||||
WBPaper00058562 | |||||||||
WBPaper00058897 | |||||||||
WBPaper00059927 | |||||||||
WBPaper00060121 | |||||||||
WBPaper00060194 | |||||||||
WBPaper00060485 | |||||||||
WBPaper00060722 | |||||||||
WBPaper00060809 | |||||||||
WBPaper00064037 | |||||||||
WBPaper00064432 | |||||||||
WBPaper00064466 | |||||||||
WBPaper00064619 | |||||||||
WBPaper00064712 | |||||||||
WBPaper00064917 | |||||||||
WBPaper00065118 | |||||||||
WBPaper00066029 | |||||||||
WBPaper00066135 | |||||||||
Remark | Sequence connection from [Bamber BA] | ||||||||
Method | Gene |