e2008 : adult male has swollen bursa ES3 ME1. Adult hermaphrodite has protruding vulva ES2. Weak suppressor of some tra mutations. NA4.
See also e2164, e2261, e2423, ma114, ma122, ma123, ma128
[C.elegansII] e2008 : adult male has swollen bursa, ES3 ME1. Adult hermaphrodite has protruding vulva ES2. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate. OA>10: e2423, ma114, ma122, r863, r920::Tc4,r908 (deletion), etc. Cloned: encodes predicted protein with 36-69% similarity to yeast UPF1. [Hodgkin et al. 1989; Pulak and Anderson 1993; TR]
Enables protein phosphatase 2A binding activity. Involved in embryonic genitalia morphogenesis; ncRNA metabolic process; and negative regulation of gene expression. Located in cytoplasm and nucleus. Expressed in intestinal cell and muscle cell. Is an ortholog of human UPF1 (UPF1 RNA helicase and ATPase).