n372 : V1-V4 divide like V5 resulting in multiple ectopic postdeirids in hermaphrodites and males and multiple ectopic rays in males. Males also have hermaphroditic Pn.p's and are mostly missing lateral alae. ES1 (hermaphrodite) ES2 (male). ME2. NA1.
lin-22 encodes a basic helix-loop-helix (bHLH)-containing protein that is homologous to the Drosophila hairy/Enhancer of split transcriptional repressors; during postembryonic development, lin-22 activity is required for patterning of midbody epidermal and neuronal lineages.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be located in nucleus. Expressed in seam cell. Human ortholog(s) of this gene implicated in hemangiopericytoma. Is an ortholog of human HES1 (hes family bHLH transcription factor 1).