WormBase Tree Display for Variation: WBVar00089461

WBVar00089461 Evidence: Person_evidence: WBPerson23830
  Name: Public_name: n372
    Other_name: CE26703:p.Glu30Lys
      Y54G2A.1.1:c.88G>A
    HGVSg: CHROMOSOME_IV:g.3019924G>A
  Sequence_details: SMap: S_parent: Sequence: Y54G2A
    Flanking_sequences: caacattttcagaaaaacaaacctctaatg agaagaaacggagagctcgaataaacaagt
    Mapping_target: Y54G2A
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004555
      WBStrain00004801
      WBStrain00004805
      WBStrain00004806
      WBStrain00026726
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00003008
    Transcript: Y54G2A.1.1 (12)
  Genetics: Interpolated_map_position: IV -6.65615
    Mapping_data: In_multi_point: 683
        684
        691
  Description: Phenotype: WBPhenotype:0001411 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Males show ectopic WGA surface binding. 20% self-fertile XX animals transformed with her-1 show WGA surface binding characteristic of lin-22(n372) males. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: See materials and methods for detailed lectin binding treatment. Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
          Genotype: her-1(y101) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0002496 Paper_evidence: WBPaper00056582
        Curator_confirmed: WBPerson712
        Remark: While wild-type animals only display a single dat-1::gfp(+) neuron pair in the midbody region, the PDE neuron pair from the postdeirid lineage, all 4 mutant alleles display ectopic dat1::gfp expression along the anterior/posterior axis of the animal Paper_evidence: WBPaper00056582
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006747 PATO:0000460 Paper_evidence: WBPaper00056582
                Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00006052
    WBPaper00022140
    WBPaper00013704
    WBPaper00001576
    WBPaper00014771
    WBPaper00016173
    WBPaper00016309
    WBPaper00013803
    WBPaper00016477
    WBPaper00056582
  Remark: alt_det = g to a mut_det = E(30)K Person_evidence: WBPerson23830
      Curator_confirmed: WBPerson51134
    Sequence data from The role of lin-22, a hairy/Enhancer of split homolog, in patterning the peripheral nervous system of C. elegans, Lisa A. Wrischnik and Cynthia J. Kenyon, Development, 1997 Person_evidence: WBPerson23830
      Curator_confirmed: WBPerson51134
    Variation information submitted by WBPerson23830 on 2021-05-7_10:00:52 via the Allele submission form. Curator_confirmed: WBPerson51134
  Method: Substitution_allele