WormBase Tree Display for Gene: WBGene00001964
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| WBGene00001964 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C17C3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hlh-25 | Person_evidence | WBPerson346 | |||||
| Sequence_name | C17C3.7 | ||||||||
| Molecular_name | C17C3.7 | ||||||||
| C17C3.7.1 | |||||||||
| CE42919 | |||||||||
| Other_name | CELE_C17C3.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | hlh-25 | ||||||||
| DB_info | Database | AceView | gene | 2F825 | |||||
| WormQTL | gene | WBGene00001964 | |||||||
| WormFlux | gene | WBGene00001964 | |||||||
| NDB | locus_tag | CELE_C17C3.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001964|UniProtKB=Q18054 | |||||||
| family | PTHR10985 | ||||||||
| NCBI | gene | 182717 | |||||||
| RefSeq | protein | NM_062662.3 | |||||||
| SwissProt | UniProtAcc | Q18054 | |||||||
| TREEFAM | TREEFAM_ID | TF322171 | |||||||
| UniProt_GCRP | UniProtAcc | Q18054 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hlh | ||||||||
| Allele (12) | |||||||||
| Strain | WBStrain00036426 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (22) | |||||||||
| Paralog | WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001966 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 | |||||
| WBPaper00025235 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Apr 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSpa; anal depressor muscle; body wall musculature; intestinal cell; and neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C17C3.7 | |||||||
| Corresponding_CDS_history | C17C3.7:wp193 | ||||||||
| Corresponding_transcript | C17C3.7.1 | ||||||||
| Associated_feature | WBsf978550 | ||||||||
| Transcription_factor | WBTranscriptionFactor000072 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00010899 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084010 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040773 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024579 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040785 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027179 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3495 | ||||||||
| Expr8067 | |||||||||
| Expr12501 | |||||||||
| Expr1144824 | |||||||||
| Expr2012500 | |||||||||
| Expr2030739 | |||||||||
| Drives_construct | WBCnstr00005197 | ||||||||
| WBCnstr00011427 | |||||||||
| WBCnstr00021040 | |||||||||
| WBCnstr00021041 | |||||||||
| WBCnstr00036556 | |||||||||
| Construct_product | WBCnstr00005197 | ||||||||
| WBCnstr00021041 | |||||||||
| WBCnstr00036556 | |||||||||
| Regulate_expr_cluster | WBPaper00048624:hlh-25(ok1710)_downregulated | ||||||||
| WBPaper00048624:hlh-25(ok1710)_upregulated | |||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (32) | |||||||||
| Interaction (59) | |||||||||
| Map_info | Map | II | Position | -1.19086 | Error | 0.002255 | |||
| Positive | Positive_clone | C17C3 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00025235 | ||||||||
| WBPaper00026325 | |||||||||
| WBPaper00027287 | |||||||||
| WBPaper00027309 | |||||||||
| WBPaper00029033 | |||||||||
| WBPaper00034761 | |||||||||
| WBPaper00043858 | |||||||||
| WBPaper00048624 | |||||||||
| WBPaper00061738 | |||||||||
| WBPaper00062117 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
