WormBase Tree Display for Gene: WBGene00006786

WBGene00006786 SMap: S_parent: Sequence: Y60A3A
  Identity: Version: 2
    Name: CGC_name: unc-51 Person_evidence: WBPerson261
      Sequence_name: Y60A3A.1
      Molecular_name: Y60A3A.1
        Y60A3A.1.1
        CE24516
      Other_name: frs-2 Accession_evidence: EMBL AB096637
        atg-1 Person_evidence: WBPerson649
        CELE_Y60A3A.1 Accession_evidence: NDB BX284605
      Public_name: unc-51
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Feb 2008 11:29:00 WBPerson2970 Name_change: Other_name: atg-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143154
    Allele (371)
    Legacy_information: e369 : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid phasmid PDE axons abnormal; suppressed by sup-4. ES3 ME0. NA6 (e389 e432 etc.).
      See also e432, e584, e1120, e1189, e1212
      [C.elegansII] e369amb : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid, phasmid, PDE and other axons abnormal; multiple defects in axon elongation, fasciculation,etc. Abnormal axon ultrastructure: varicosities, cisternae, abnormal vesicles.ES3 ME0. OA>10: e389, e432, e584, e1212 etc. Cloned: 3.1 kb transcript, encodes predicted 856 aa protein with similarity to Ser/Thrkinases. unc-51: lacZ expressed in neurons. [Hedgecock et al. 1985; McIntire et al. 1992; Ogura et al. 1994; FK; FR]
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (61)
    Ortholog: WBGene00063614 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00042703 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00042704 Caenorhabditis briggsae From_analysis: OrthoMCL
            WormBase-Compara
      WBGene00157830 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00126501 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00145632 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00227200 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g283 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g4799 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g4377 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g4378 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7307 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1157 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g2285 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6736 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g6737 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g5998 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g28235 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g3798 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g3799 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00431.g10768 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g21737 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_V.g21738 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold75.g464 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold75.g465 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01457.g21030 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_01457.g21031 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_01457.g21032 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_19593 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_19594 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022023 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_022024 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04952 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8044 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50430200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g18013 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00082853 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00245050 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00114237 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00259465 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00297386 Trichuris muris From_analysis: WormBase-Compara
      WBGene00300925 Trichuris muris From_analysis: WormBase-Compara
      WBGene00300930 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003148 Saccharomyces cerevisiae From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0260945 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-071203-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-080723-31 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-090218-30 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:12558 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:13480 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1270126 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1352758 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310181 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1589743 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00013694 Caenorhabditis elegans From_analysis: Panther
      WBGene00013643 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins; unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration; in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14; in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals; UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles; in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5. Paper_evidence: WBPaper00002050
            WBPaper00002845
            WBPaper00004362
            WBPaper00006070
            WBPaper00024595
            WBPaper00028376
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 21 Jul 2008 00:00:00
      Automated_description: Enables protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of axon extension. Located in axon and neuronal cell body. Expressed in body wall musculature; motor neurons; pharyngeal muscle cell; and touch receptor neurons. Is an ortholog of human ULK1 (unc-51 like autophagy activating kinase 1) and ULK2 (unc-51 like autophagy activating kinase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y60A3A.1
    Corresponding_transcript: Y60A3A.1.1
    Other_sequence (65)
    Associated_feature: WBsf669876
      WBsf669877
      WBsf982087
      WBsf1003406
      WBsf1021857
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr731
      Expr1492
      Expr12441
      Expr15294
      Expr1021306
      Expr1032857
      Expr1161234
      Expr2017884
      Expr2036020
    Drives_construct (17)
    Construct_product (3)
    Microarray_results (20)
    Expression_cluster (150)
    Interaction (96)
    WBProcess: WBbiopr:00000003
  Map_info: Map: V Position: 24.4326 Error: 0.019149
    Well_ordered
    Positive: Inside_rearr: ozDf1
        ozDf2
      Positive_clone: Y60A3A Inferred_automatically: From sequence, transcript, pseudogene data
        YO#KOPUF
    Mapping_data: 2_point (12)
      Multi_point (36)
      Pos_neg_data: 298
        2143
        8972
        8980
    Landmark_gene
  Reference (191)
  Method: Gene