WormBase Tree Display for Gene: WBGene00006768

WBGene00006768 SMap: S_parent: Sequence: ZK637
  Identity: Version: 1
    Name: CGC_name: unc-32 Person_evidence: WBPerson261
      Sequence_name: ZK637.8
      Molecular_name (18)
      Other_name: CELE_ZK637.8 Accession_evidence: NDB BX284603
      Public_name: unc-32
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143023
    Allele (71)
    Possibly_affected_by: WBVar02157789
      WBVar02157790
    Legacy_information: e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation).
      [Thierry-Mieg]
      See also eIs16, f120, f121, f123
      [C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC]
    Strain: WBStrain00022519
      WBStrain00022527
      WBStrain00022529
      WBStrain00022530
      WBStrain00022531
      WBStrain00022532
      WBStrain00022539
      WBStrain00022540
      WBStrain00022542
      WBStrain00022555
      WBStrain00024105
      WBStrain00026496
      WBStrain00026585
      WBStrain00026735
      WBStrain00026750
      WBStrain00026758
      WBStrain00026838
      WBStrain00026842
      WBStrain00026897
      WBStrain00026912
      WBStrain00026913
      WBStrain00026965
      WBStrain00026966
      WBStrain00027025
      WBStrain00027026
      WBStrain00027088
      WBStrain00027111
      WBStrain00027139
      WBStrain00027169
      WBStrain00027176
      WBStrain00027184
      WBStrain00027185
      WBStrain00027607
      WBStrain00027608
      WBStrain00027612
      WBStrain00028754
      WBStrain00029348
      WBStrain00029349
      WBStrain00030728
      WBStrain00030730
      WBStrain00030732
      WBStrain00030873
      WBStrain00030927
      WBStrain00033369
      WBStrain00033503
      WBStrain00034125
      WBStrain00034243
      WBStrain00034244
      WBStrain00034476
      WBStrain00034477
      WBStrain00034478
      WBStrain00034484
      WBStrain00034635
      WBStrain00035091
      WBStrain00035094
      WBStrain00035095
      WBStrain00035097
      WBStrain00035109
      WBStrain00040415
      WBStrain00000378
      WBStrain00000433
      WBStrain00000753
      WBStrain00000754
      WBStrain00000755
      WBStrain00000756
      WBStrain00000757
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      WBStrain00000759
      WBStrain00000760
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      WBStrain00000762
      WBStrain00000763
      WBStrain00000764
      WBStrain00000765
      WBStrain00000766
      WBStrain00000767
      WBStrain00000768
      WBStrain00000769
      WBStrain00000770
      WBStrain00000771
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      WBStrain00000786
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      WBStrain00000790
      WBStrain00000791
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      WBStrain00000796
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      WBStrain00000800
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      WBStrain00000806
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      WBStrain00000812
      WBStrain00000813
      WBStrain00000814
      WBStrain00000829
      WBStrain00000830
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      WBStrain00000844
      WBStrain00000846
      WBStrain00000847
      WBStrain00000856
      WBStrain00000861
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      WBStrain00000863
      WBStrain00000864
      WBStrain00000865
      WBStrain00000866
      WBStrain00000867
      WBStrain00000868
      WBStrain00000869
      WBStrain00000870
      WBStrain00000871
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      WBStrain00000873
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      WBStrain00000876
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      WBStrain00000880
      WBStrain00000881
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      WBStrain00000887
      WBStrain00000888
      WBStrain00000889
      WBStrain00000890
      WBStrain00000891
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      WBStrain00000894
      WBStrain00000895
      WBStrain00000896
      WBStrain00000897
      WBStrain00000898
      WBStrain00000899
      WBStrain00000900
      WBStrain00000901
      WBStrain00000902
      WBStrain00000903
      WBStrain00000904
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      WBStrain00000906
      WBStrain00000907
      WBStrain00000908
      WBStrain00000909
      WBStrain00000910
      WBStrain00000911
      WBStrain00000912
      WBStrain00000913
      WBStrain00000941
      WBStrain00000962
      WBStrain00003855
      WBStrain00003939
      WBStrain00003943
      WBStrain00003986
      WBStrain00004123
      WBStrain00004363
      WBStrain00004375
      WBStrain00004376
      WBStrain00004381
      WBStrain00004540
      WBStrain00004575
      WBStrain00005035
      WBStrain00005231
      WBStrain00005484
      WBStrain00005645
      WBStrain00005646
      WBStrain00005647
      WBStrain00005648
      WBStrain00005650
      WBStrain00005651
      WBStrain00005652
      WBStrain00006200
      WBStrain00006201
      WBStrain00006202
      WBStrain00006240
      WBStrain00006254
      WBStrain00006442
      WBStrain00007117
      WBStrain00007142
      WBStrain00007394
      WBStrain00007477
      WBStrain00007478
      WBStrain00007479
      WBStrain00007480
      WBStrain00007744
      WBStrain00007747
      WBStrain00007748
      WBStrain00007749
      WBStrain00007750
      WBStrain00007751
      WBStrain00007752
      WBStrain00007753
      WBStrain00007754
      WBStrain00007755
      WBStrain00007756
      WBStrain00007757
      WBStrain00007758
      WBStrain00007759
      WBStrain00007760
      WBStrain00007761
      WBStrain00007762
      WBStrain00007763
      WBStrain00007764
      WBStrain00007765
      WBStrain00007766
      WBStrain00007767
      WBStrain00007768
      WBStrain00007769
      WBStrain00007770
      WBStrain00007771
      WBStrain00007772
      WBStrain00007774
      WBStrain00007775
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      WBStrain00007779
      WBStrain00007780
      WBStrain00007781
      WBStrain00007782
      WBStrain00007783
      WBStrain00007784
      WBStrain00007785
      WBStrain00007786
      WBStrain00007787
      WBStrain00007788
      WBStrain00007789
      WBStrain00007790
      WBStrain00007791
      WBStrain00007792
      WBStrain00007793
      WBStrain00007794
      WBStrain00007795
      WBStrain00007796
      WBStrain00007797
      WBStrain00007798
      WBStrain00007799
      WBStrain00007800
      WBStrain00007801
      WBStrain00007802
      WBStrain00007803
      WBStrain00007804
      WBStrain00007805
      WBStrain00007806
      WBStrain00007807
      WBStrain00007982
      WBStrain00007988
      WBStrain00007990
      WBStrain00007992
      WBStrain00007995
      WBStrain00008002
      WBStrain00007981
      WBStrain00008018
      WBStrain00008019
      WBStrain00008020
      WBStrain00008021
      WBStrain00008566
      WBStrain00003936
      WBStrain00022370
      WBStrain00022499
      WBStrain00051670
      WBStrain00051659
      WBStrain00051669
      WBStrain00051674
      WBStrain00051661
      WBStrain00051668
      WBStrain00051680
      WBStrain00051678
      WBStrain00051660
      WBStrain00051679
    RNASeq_FPKM (74)
    GO_annotation (28)
    Contained_in_operon: CEOP3556
    Ortholog (59)
    Paralog: WBGene00043993 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00006916 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006915 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006914 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: unc-32 encodes, by alternative splicing, six isoforms of an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); UNC-32 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); one UNC-32 isoform is essential for locomotion and normal synaptic vesicle morphology in motoneurons, is expressed solely in the nervous system, and is specifically mutated by unc-32(e189) or unc-32(f120); other UNC-32 isoforms are essential for embryonic and larval development; UNC-32 is expressed throughout the life cycle, strongly in the nervous system, but also in vulvae, spermathecal-uterine valves, intestine, and pharynx; UNC-32 is required for necrosis, since mutations of unc-32 suppress necrotic neurodegeneration and thapsigargin-induced cell death; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; alternative splicing of the unc-32 pre-mRNA is dependent on ASD-1 and FOX-1, and in neurons, is also dependent on UNC-75, which binds unc-32 intron 7a in vitro. Paper_evidence: WBPaper00004601
            WBPaper00004842
            WBPaper00025183
            WBPaper00028773
            WBPaper00028774
            WBPaper00028775
            WBPaper00042088
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 26 Mar 2013 00:00:00
      Automated_description: Predicted to enable ATPase binding activity. Involved in several processes, including cholinergic synaptic transmission; defense response to Gram-positive bacterium; and positive regulation of neurotransmitter secretion. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in several structures, including alimentary muscle; hermaphrodite gonad; neurons; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of human ATP6V0A1 (ATPase H+ transporting V0 subunit a1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070390 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:865)
      DOID:0110942 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11647)
      DOID:14219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:866)
      DOID:0112171 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18481)
      EFO:MONDO:0015827 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:866)
      DOID:0070134 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18481)
  Molecular_info: Corresponding_CDS: ZK637.8a
      ZK637.8b
      ZK637.8c
      ZK637.8d
      ZK637.8e
      ZK637.8f
    Corresponding_CDS_history: ZK637.8a:wp77
      ZK637.8b:wp77
    Corresponding_transcript: ZK637.8a.1
      ZK637.8b.1
      ZK637.8c.1
      ZK637.8d.1
      ZK637.8e.1
      ZK637.8f.1
    Other_sequence (98)
    Associated_feature (12)
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr21
      Expr848
      Expr849
      Expr2405
      Expr1026854
      Expr1032841
      Expr1163008
      Expr2017865
      Expr2036001
    Drives_construct: WBCnstr00000434
      WBCnstr00006396
      WBCnstr00010008
      WBCnstr00010009
      WBCnstr00010814
      WBCnstr00013318
      WBCnstr00017554
    Construct_product: WBCnstr00000434
      WBCnstr00006396
      WBCnstr00014414
      WBCnstr00015831
      WBCnstr00017091
      WBCnstr00017553
      WBCnstr00041445
    Microarray_results (39)
    Expression_cluster (124)
    Interaction (84)
  Map_info: Map: III Position: 0
    Well_ordered
    Positive: Inside_rearr: mnDp37
      Positive_clone: A1D10
        A1F1
        T05B2
        ZK637 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: tnDf2
    Mapping_data: 2_point (34)
      Multi_point: 64
        65
        66
        68
        70
        71
        74
        76
        77
        78
        79
        80
        86
        87
        90
        93
        218
        219
        220
        315
        325
        326
        347
        356
        384
        385
        386
        387
        388
        404
        405
        406
        407
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        412
        428
        430
        488
        491
        492
        498
        502
        506
        513
        530
        580
        581
        584
        585
        588
        589
        611
        613
        629
        630
        642
        729
        746
        753
        758
        759
        761
        855
        863
        864
        868
        870
        887
        888
        889
        890
        892
        894
        895
        1080
        1085
        1086
        1105
        1107
        1112
        1255
        1357
        1362
        1363
        1364
        1401
        1402
        1404
        1412
        1414
        1421
        1489
        1490
        1497
        1498
        1500
        1501
        1503
        1506
        1510
        1570
        1573
        1577
        1637
        1669
        1726
        1728
        1729
        1730
        1731
        1735
        1752
        1754
        1816
        1824
        1836
        1863
        2012
        2018
        2055
        2057
        2074
        2099
        2101
        2151
        2179
        2185
        2190
        2198
        2199
        2223
        2226
        2235
        2246
        2305
        2306
        2312
        2425
        2462
        2463
        2740
        2742
        2744
        2755
        2764
        2766
        3014
        3138
        3155
        3156
        3166
        3178
        3219
        3225
        3246
        3261
        3299
        3302
        3324
        3325
        3326
        3327
        3328
        3329
        3330
        3331
        3332
        3333
        3334
        3335
        3336
        3337
        3338
        3340
        3339
        3393
        3402
        3403
        3423
        3469
        3471
        3472
        3509
        3510
        3521
        3522
        3585
        3586
        3587
        3588
        3589
        3590
        3591
        3592
        3593
        3594
        3595
        3596
        3597
        3598
        3601
        3620
        3622
        3624
        3625
        3667
        3697
        3715
        3718
        3721
        3739
        3740
        3741
        3742
        3743
        3744
        3745
        3746
        3747
        3748
        3749
        3750
        3751
        3752
        3753
        3754
        3755
        3756
        3757
        3758
        3759
        3760
        3761
        3762
        3763
        3764
        3765
        3766
        3767
        3768
        3769
        3770
        3771
        3774
        3854
        3859
        3893
        3895
        3916
        3917
        3999
        4014
        4044
        4046
        4050
        4094
        4115
        4116
        5435
        5685
        5692
        5712
        5724
      Pos_neg_data: 806
        3726
        8637
        8642
        9451
    Landmark_gene
  Reference (150)
  Method: Gene