WormBase Tree Display for Gene: WBGene00003026
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| WBGene00003026 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C12C8 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-41 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C12C8.3 | ||||||||
| Molecular_name | C12C8.3a | ||||||||
| C12C8.3a.1 | |||||||||
| CE27062 | |||||||||
| C12C8.3b | |||||||||
| CE27063 | |||||||||
| C12C8.3a.2 | |||||||||
| C12C8.3b.1 | |||||||||
| C12C8.3b.2 | |||||||||
| Other_name | lin-41A | Accession_evidence | EMBL | AF195610 | |||||
| lin-41B | Accession_evidence | EMBL | AF195611 | ||||||
| lep-1 | Person_evidence | WBPerson178 | |||||||
| CELE_C12C8.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lin-41 | ||||||||
| DB_info | Database | AceView | gene | 1J912 | |||||
| WormQTL | gene | WBGene00003026 | |||||||
| WormFlux | gene | WBGene00003026 | |||||||
| NDB | locus_tag | CELE_C12C8.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003026|UniProtKB=Q9U489 | |||||||
| family | PTHR24104 | ||||||||
| NCBI | gene | 172760 | |||||||
| RefSeq | protein | NM_001025828.7 | |||||||
| NM_001025827.6 | |||||||||
| SwissProt | UniProtAcc | Q9U489 | |||||||
| UniProt_GCRP | UniProtAcc | Q9U489 | |||||||
| OMIM | gene | 618570 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 24 Aug 2005 11:43:48 | WBPerson2970 | Event | Acquires_merge | WBGene00002277 | ||||
| Name_change | Other_name | lep-1 | |||||||
| Acquires_merge | WBGene00002277 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Allele (158) | |||||||||
| Possibly_affected_by | WBVar02154106 | ||||||||
| Legacy_information | [C.elegansII] ma104 : heterochronic defect in L4/A switch. [VT] | ||||||||
| [Fitch DHA] lep for LEPtoderan tail bx37 male tail tip is pointy and protrudes beyond the posterior edge of the fan. No hermaphrodite phenotype. | |||||||||
| [C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92% penetrant). [DF] | |||||||||
| Strain (11) | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (33) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | lin-41 encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins; lin-41 is a heterochronic gene required for temporal control of specific postembryonic cell fates; lin-41 is also required for proper male tail morphogenesis; lin-41 translation is negatively regulated during L4 and adult stages by the let-7 microRNA that binds to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. | Paper_evidence | WBPaper00004111 | |||||
| WBPaper00005067 | |||||||||
| WBPaper00006376 | |||||||||
| WBPaper00026761 | |||||||||
| WBPaper00027716 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Aug 2009 00:00:00 | ||||||||
| Automated_description | Enables mRNA binding activity and translation repressor activity. Involved in several processes, including negative regulation of gene expression; regulation of developmental process; and reproductive process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Part of messenger ribonucleoprotein complex. Expressed in several structures, including germ cell; hypodermal cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human TRIM71 (tripartite motif containing 71). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:32669) | ||||
| Molecular_info | Corresponding_CDS | C12C8.3a | |||||||
| C12C8.3b | |||||||||
| Corresponding_CDS_history | C12C8.3:wp47 | ||||||||
| Corresponding_transcript | C12C8.3a.1 | ||||||||
| C12C8.3a.2 | |||||||||
| C12C8.3b.1 | |||||||||
| C12C8.3b.2 | |||||||||
| Other_sequence | AF195610 | ||||||||
| AF195611 | |||||||||
| Dviv_isotig12438 | |||||||||
| JI165183.1 | |||||||||
| Acan_isotig20235 | |||||||||
| Acan_isotig08095 | |||||||||
| CRC06076_1 | |||||||||
| Oden_isotig18608 | |||||||||
| Associated_feature (11) | |||||||||
| Transcription_factor | WBTranscriptionFactor000740 | ||||||||
| Experimental_info | RNAi_result (64) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00005481 | ||||||||
| WBCnstr00005483 | |||||||||
| WBCnstr00008154 | |||||||||
| WBCnstr00017544 | |||||||||
| WBCnstr00017545 | |||||||||
| WBCnstr00018650 | |||||||||
| WBCnstr00019726 | |||||||||
| WBCnstr00019727 | |||||||||
| WBCnstr00036277 | |||||||||
| Regulate_expr_cluster | WBPaper00050717:let-7(n2853)_lin-41(xe11)_downregulated | ||||||||
| WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated | |||||||||
| WBPaper00051310:LIN-41_interacting | |||||||||
| Antibody | WBAntibody00002538 | ||||||||
| WBAntibody00002566 | |||||||||
| WBAntibody00002567 | |||||||||
| WBAntibody00002954 | |||||||||
| Microarray_results | SMD_C12C8.3 | ||||||||
| 175677_s_at | |||||||||
| 187703_s_at | |||||||||
| A_12_P104652 | |||||||||
| A_12_P157705 | |||||||||
| Aff_C12C8.3 | |||||||||
| GPL13394_WBGene00003026 | |||||||||
| GPL13914_C12C8.3 | |||||||||
| GPL14144_C12C8.3a_2470-2529_0.894_9_B | |||||||||
| GPL14144_C12C8.3a_2755-2814_0.909_4_C | |||||||||
| GPL14144_C12C8.3a_3089-3148_0.941_1_A | |||||||||
| GPL19516_CGZ0004301 | |||||||||
| GPL19516_CGZ0004302 | |||||||||
| GPL19516_CGZ0004303 | |||||||||
| GPL19516_CGZ0004304 | |||||||||
| GPL21109_C12C8.3a.1 | |||||||||
| GPL21109_C12C8.3a.2 | |||||||||
| GPL21109_C12C8.3b.1 | |||||||||
| GPL3518_CE27062 | |||||||||
| GPL8304_CE_WBGene00003026_A | |||||||||
| GPL8673_C12C8_3aP02348 | |||||||||
| GPL8673_C12C8_3aP02825 | |||||||||
| GPL8673_C12C8_3aP03019 | |||||||||
| GPL8673_C12C8_3bP02336 | |||||||||
| GPL8673_C12C8_3bP02813 | |||||||||
| GPL8673_C12C8_3bP03007 | |||||||||
| Expression_cluster (211) | |||||||||
| Interaction (269) | |||||||||
| WBProcess | WBbiopr:00000020 | ||||||||
| WBbiopr:00000057 | |||||||||
| WBbiopr:00000083 | |||||||||
| Map_info | Map | I | Position | 3.75248 | Error | 0.000711 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C12C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 3934 | |||||||
| Multi_point | 1445 | ||||||||
| 5072 | |||||||||
| 5602 | |||||||||
| 3193 | |||||||||
| 3194 | |||||||||
| 3195 | |||||||||
| 3196 | |||||||||
| 3197 | |||||||||
| 3198 | |||||||||
| 3199 | |||||||||
| Pos_neg_data | 3935 | ||||||||
| 8519 | |||||||||
| 8520 | |||||||||
| 8521 | |||||||||
| 8522 | |||||||||
| 8523 | |||||||||
| 8524 | |||||||||
| 8525 | |||||||||
| Reference (217) | |||||||||
| Remark | inx-20 and lep-1 has been merged in WS89 and unmerged in WS104 due to SNP mapping evidence. Unmerging also unlinks its other_name opu-20 which is an other_name of inx-20 | Person_evidence | WBPerson178 | ||||||
| Method | Gene |
