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WormBase Tree Display for Gene: WBGene00001993

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Name Class

WBGene00001993EvidenceCGC_data_submission
SMapS_parentSequenceT21C12
IdentityVersion1
NameCGC_namehpd-1Person_evidenceWBPerson545
Sequence_nameT21C12.2
Molecular_nameT21C12.2
T21C12.2.1
CE02347
Other_nameCELE_T21C12.2Accession_evidenceNDBBX284603
Public_namehpd-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhpd
Allele (40)
Legacy_informationRNAi of hpd-1 modestly extends C. elegans lifespan, and weakly inhibits dauer recovery of daf-2(e1370) at 22C.Person_evidenceWBPerson3621
StrainWBStrain00036676
Component_of_genotypeWBGenotype00000123
WBGenotype00000125
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (38)
ParalogWBGene00016294Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionhpd-1 encodes a putative 4-hydroxyphenylpyruvate dioxygenase requiredfor normally short lifespan and for negative regulation of the dauer larval stage, with loss of hpd-1 function prolonging lifespan andpromoting dauer formation; hpd-1 is a (perhaps evolutionarily conserved)target of transcriptional activation by DAF-16; HPD-1 is orthologous tohuman HPD (OMIM:609695, mutated in tyrosinemia type III), and isparalogous to C31H2.4 and human HPDL/GLOXD1; HPD-1 is expressed inhypodermis and intestine, and is required for the tyrosinemic phenotypeof K10C2.4(RNAi) animals.Paper_evidenceWBPaper00005813
WBPaper00006525
WBPaper00031006
WBPaper00031468
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated02 Mar 2008 00:00:00
Automated_descriptionPredicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Is an ortholog of human HPD (4-hydroxyphenylpyruvate dioxygenase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111362Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5147)
DOID:0050727Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5147)
Molecular_infoCorresponding_CDST21C12.2
Corresponding_transcriptT21C12.2.1
Other_sequence (379)
Associated_featureWBsf654990
WBsf654991
WBsf981567
WBsf994063
WBsf994064
WBsf1015811
Experimental_infoRNAi_result (12)
Expr_patternChronogram35
Expr6728
Expr7956
Expr1020699
Expr1031158
Expr1157260
Expr2012550
Expr2030787
Drives_constructWBCnstr00003270
WBCnstr00036534
Construct_productWBCnstr00036534
Microarray_resultsSMD_T21C12.2
193009_at
A_12_P108561
A_12_P175142
A_12_P175143
Aff_T21C12.2
GPL13394_WBGene00001993
GPL13914_T21C12.2
GPL14144_T21C12.2_1045-1104_0.969_1_A
GPL14144_T21C12.2_799-858_0.922_10_C
GPL14144_T21C12.2_927-986_0.940_5_B
GPL19516_CGZ0035859
GPL21109_T21C12.2
GPL3518_CE02347
GPL8304_CE_WBGene00001993_A
GPL8304_CE_WBGene00001993_B
GPL8304_CE_WBGene00001993_C
GPL8673_T21C12_2P00122
GPL8673_T21C12_2P00382
GPL8673_T21C12_2P00998
GPL9450_T21C12.2
cea2.p.74438
Expression_cluster (244)
Interaction (26)
Map_infoMapIIIPosition3.48495Error0.062473
PositivePositive_cloneT21C12Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00005813
WBPaper00031468
WBPaper00034325
WBPaper00038491
WBPaper00038936
WBPaper00049828
WBPaper00055090
WBPaper00065140
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene