WormBase Tree Display for Gene: WBGene00000103
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WBGene00000103 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | akt | ||||||
Allele (204) | |||||||
Legacy_information | [Paradis S] No mutants known. Encodes AKT kinase, related to akt-1. Overexpression does not suppress age-1. akt-2::GFP is widely expressed. Inhibition of akt-2 by RNAi has no obvious phenotype, inhibition of both akt-2 and akt-1 leads to dauer-constitutive phenotype. Predicted gene F28H6.1 | ||||||
Strain | WBStrain00023654 | ||||||
WBStrain00035581 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00100948 | ||||||
00100949 | |||||||
00100950 | |||||||
00100951 | |||||||
00100952 | |||||||
00100953 | |||||||
00100954 | |||||||
00100955 | |||||||
00100956 | |||||||
00100957 | |||||||
00100958 | |||||||
00100959 | |||||||
00100960 | |||||||
00100961 | |||||||
00100962 | |||||||
00100963 | |||||||
00100964 | |||||||
00100965 | |||||||
00100966 | |||||||
00100967 | |||||||
00100968 | |||||||
00100969 | |||||||
00100970 | |||||||
00100971 | |||||||
00106790 | |||||||
00106791 | |||||||
00106792 | |||||||
00106793 | |||||||
Ortholog (35) | |||||||
Paralog (14) | |||||||
Structured_description | Concise_description | akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. | Paper_evidence | WBPaper00003173 | |||
WBPaper00003568 | |||||||
WBPaper00005614 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (38) | ||||||
Molecular_info | Corresponding_CDS | F28H6.1a | |||||
F28H6.1b | |||||||
Corresponding_transcript | F28H6.1a.1 | ||||||
F28H6.1b.1 | |||||||
Other_sequence | AF072381 | ||||||
Associated_feature | WBsf1007837 | ||||||
WBsf1007838 | |||||||
WBsf1024363 | |||||||
WBsf236648 | |||||||
WBsf236649 | |||||||
WBsf236650 | |||||||
WBsf236651 | |||||||
WBsf236652 | |||||||
Experimental_info | RNAi_result (44) | ||||||
Expr_pattern | Expr1409 | ||||||
Expr4144 | |||||||
Expr11783 | |||||||
Expr14932 | |||||||
Expr1020215 | |||||||
Expr1030053 | |||||||
Expr1149774 | |||||||
Expr2009284 | |||||||
Expr2027521 | |||||||
Drives_construct | WBCnstr00010265 | ||||||
WBCnstr00015111 | |||||||
WBCnstr00021718 | |||||||
WBCnstr00037730 | |||||||
WBCnstr00041589 | |||||||
Construct_product | WBCnstr00010265 | ||||||
WBCnstr00015111 | |||||||
WBCnstr00037730 | |||||||
Microarray_results (30) | |||||||
Expression_cluster (189) | |||||||
Interaction (149) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000025 | |||||||
WBbiopr:00000039 | |||||||
WBbiopr:00000074 | |||||||
Map_info | Map | X | Position | 16.5504 | Error | 0.017286 | |
Positive | Positive_clone | F28H6 | Person_evidence | WBPerson1350 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
R03E1 | Person_evidence | WBPerson1350 | |||||
Mapping_data | Multi_point | 4152 | |||||
Pseudo_map_position | |||||||
Reference (113) | |||||||
Picture | WBPicture0000013078 | ||||||
Remark | Data extracted from Paradis & Ruvkun (1998) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |