WormBase Tree Display for Gene: WBGene00002215

WBGene00002215 SMap: S_parent: Sequence: C18C4
  Identity: Version: 1
    Name: CGC_name: klc-2 Person_evidence: WBPerson589
      Sequence_name: C18C4.10
      Molecular_name (11)
      Other_name: CELE_C18C4.10 Accession_evidence: NDB BX284605
      Public_name: klc-2
    DB_info: Database: AceView gene 5G58
        WormQTL gene WBGene00002215
        WormFlux gene WBGene00002215
        NDB locus_tag CELE_C18C4.10
        Panther gene CAEEL|WormBase=WBGene00002215|UniProtKB=P46822
          family PTHR45783
        NCBI gene 178942
        RefSeq protein NM_001028493.7
            NM_001028494.5
            NM_001028492.5
        SwissProt UniProtAcc P46822
        UniProt_GCRP UniProtAcc P46822
        OMIM gene 611729
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: klc
    Allele (67)
    Legacy_information: [Siddiqui SS ] Predicted gene C18C4.10. Related to kinesin light chain by sequence similarity.
    Strain: WBStrain00001630
      WBStrain00050735
    RNASeq_FPKM (74)
    GO_annotation: 00046586
      00046587
      00046588
      00046589
      00046590
      00046591
      00046592
      00046593
      00046594
      00046595
      00046596
      00046597
      00046598
      00046599
      00046600
      00046601
      00046602
      00046603
      00046604
      00046605
      00046606
      00046607
      00046608
      00046609
      00046610
      00046611
      00046612
      00046613
      00046614
      00046615
      00046616
      00110189
    Ortholog: WBGene00058915 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00030964 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00030965 Caenorhabditis briggsae From_analysis: OrthoMCL
            WormBase-Compara
      WBGene00143153 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00145025 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00154291 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00193909 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00138153 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00091182 Pristionchus pacificus From_analysis: OMA
      WBGene00222560 Brugia malayi From_analysis: WormBase-Compara
      WBGene00228530 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229293 Brugia malayi From_analysis: WormBase-Compara
      WBGene00231707 Brugia malayi From_analysis: WormBase-Compara
      WBGene00232560 Brugia malayi From_analysis: WormBase-Compara
      WBGene00268381 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2116 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g15081 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8949 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g15818 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g14180 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g18009 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g102 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9915 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21812 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g24629 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00246.g7820 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g19687 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_V.g19689 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold460.g1464 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00484.g11964 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_07969.g38312 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_12026 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_017760 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g00164 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g7523 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g7527 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50196610 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g14268 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243193 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00264614 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285072 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296864 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0010235 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1599 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050417-350 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060929-772 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:6387 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:20716 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:21624 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:20717 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      MGI:107978 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:107953 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1922014 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1277971 Mus musculus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:621411 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621432 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:1307377 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1306555 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00002214 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: klc-2 encodes a kinesin light chain; klc-2 is required for transport and localization of synaptic vesicles to presynaptic terminals; in addition, klc-2 is required for normal translocation of the meiotic spindle to the oocyte cortex; KLC-2 physically interacts with UNC-116/kinesin heavy chain (KHC) and with UNC-16 and UNC-14, suggesting that it regulates vesicular transport by mediating the association between UNC-116/KHC and synaptic vesicles; a KLC-2::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, KLC-2::GFP exhibits diffuse localization. Paper_evidence: WBPaper00004211
            WBPaper00005014
            WBPaper00005076
            WBPaper00024617
            WBPaper00025176
            WBPaper00026866
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 13 Mar 2009 00:00:00
      Automated_description: Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of organelle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Expressed in body ganglion; muscle cell; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
      DOID:2378 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
      DOID:0060491 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20716)
  Molecular_info: Corresponding_CDS: C18C4.10a
      C18C4.10b
      C18C4.10c
    Corresponding_CDS_history: C18C4.10b:wp90
      C18C4.10d:wp261
    Corresponding_transcript: C18C4.10a.1
      C18C4.10b.1
      C18C4.10b.2
      C18C4.10b.3
      C18C4.10c.1
    Other_sequence (99)
    Associated_feature (19)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Chronogram513
      Expr3209
      Expr5301
      Expr8662
      Expr1012871
      Expr1031295
      Expr1144957
      Expr2012948
      Expr2031180
    Drives_construct: WBCnstr00002469
      WBCnstr00036381
    Construct_product: WBCnstr00036381
    Antibody: WBAntibody00001660
      WBAntibody00002831
    Microarray_results (43)
    Expression_cluster (138)
    Interaction (91)
  Map_info: Map: V Position: -1.48452 Error: 0.026086
    Positive: Positive_clone: C18C4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4462
        4944
        5254
    Pseudo_map_position
  Reference (36)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene