WormBase Tree Display for Gene: WBGene00044621

WBGene00044621 SMap: S_parent: Sequence: F53B1
  Identity: Version: 2
    Name: CGC_name: bus-5 Person_evidence: WBPerson261
      Sequence_name: F53B1.4
      Molecular_name: F53B1.4
        F53B1.4.1
        CE04644
      Other_name: CELE_F53B1.4 Accession_evidence: NDB BX284606
      Public_name: bus-5
    DB_info: Database: NDB locus_tag CELE_F53B1.4
        NCBI gene 180525
        RefSeq protein NM_075989.3
        TREEFAM TREEFAM_ID TF313892
        TrEMBL UniProtAcc Q20697
        UniProt_GCRP UniProtAcc Q20697
        OMIM gene 616146
    Species: Caenorhabditis elegans
    History: Version_change: 1 01 Sep 2005 10:24:02 WBPerson2970 Event: Created
        2 30 Jul 2020 16:54:45 WBPerson1983 Event: Acquires_merge: WBGene00018737
      Acquires_merge: WBGene00018737
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bus
    Reference_allele: WBVar00144919
    Allele (37)
    Strain: WBStrain00004659
      WBStrain00004661
      WBStrain00004730
      WBStrain00004731
      WBStrain00004762
      WBStrain00005604
    RNASeq_FPKM (74)
    Ortholog (30)
    Paralog (13)
    Structured_description: Concise_description: bus-5 is an uncloned gene required for colonization by Microbacterium nematophilum, the tail-swelling response to M. nematophilum infection, and for fully normal cuticle antigens and traction during movement; bus-5 is also strongly required for cuticle integrity and for long-term survival during starvation. Paper_evidence: WBPaper00026735
            WBPaper00029153
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 Jul 2007 00:00:00
      Automated_description: Expressed in hyp7 syncytium; hypodermal cell; and seam cell. Human ortholog(s) of this gene implicated in Catel Manzke syndrome. Is predicted to encode a protein with the following domains: NAD(P)-binding domain; NAD(P)-binding domain superfamily; and GDP-mannose 4,6 dehydratase. Is an ortholog of human TGDS (TDP-glucose 4,6-dehydratase). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081122 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20324)
  Molecular_info: Corresponding_CDS: F53B1.4
    Corresponding_transcript: F53B1.4.1
    Other_sequence (57)
    Associated_feature: WBsf237051
      WBsf237052
  Experimental_info: RNAi_result: WBRNAi00015469 Inferred_automatically: RNAi_primary
      WBRNAi00032665 Inferred_automatically: RNAi_primary
      WBRNAi00025578 Inferred_automatically: RNAi_primary
      WBRNAi00048070 Inferred_automatically: RNAi_primary
      WBRNAi00025577 Inferred_automatically: RNAi_primary
      WBRNAi00027359 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15742
      Expr15743
      Expr15744
      Expr16442
      Expr1014478
      Expr1038066
      Expr1151881
      Expr2004032
      Expr2022254
    Drives_construct: WBCnstr00026306
      WBCnstr00042503
      WBCnstr00042504
      WBCnstr00043024
    Construct_product: WBCnstr00026306
    Microarray_results (18)
    Expression_cluster: WBPaper00005432:xbp-1(zc12)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_CoreEnriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00041954:ethanol_upregulated
      WBPaper00042034:NO_upregulated_hsf-1(sy441)
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00046805:P-granule-RNAi_downregulated_Set1
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053657:N2_M.humicola-infection_12hr
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_adult
      WBPaper00056169:rrf-3(pk1426)_downregulated_L3
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_L2
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057149:prgn-1(tm985)_downregulated
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059254:CSR-1_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060273:vrk-1(RNAi)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated
      WBPaper00060886:spr-5(by101)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:M.braciatum_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:skpo-1(ok1640)_upregulated_OP50
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:B_F_K_Kp_U_Y
      WBPaper00061340:Hypodermis
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:agmo-1_5527-F53B1.4
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064291:antimycin_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065029:cadmium_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065841:82_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00066004:tdp-1(csb38)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_4_6
      cgc4489_group_8
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_E
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00032948:MoltOssilate
      WBPaper00034739:N2lessDR1350
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040116:pRJ-FR.5_down_regulated
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040876:mir-35_downregulated
      WBPaper00041207:CE_dauer_down
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00042574:rde-1(ne219)_OrsayVirus_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00055435:MUA-AuNP-0.5_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_B
    Interaction: WBInteraction000538982
      WBInteraction000558533
      WBInteraction000565990
      WBInteraction000576110
      WBInteraction000576669
      WBInteraction000579498
    WBProcess: WBbiopr:00000039
  Map_info: Map: X Position: -17.0437
    Positive: Positive_clone: F53B1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5461
  Reference (12)
  Remark: [2020-07-30T16:54:45.386Z WBPerson1983] Gene Merged: bus-5 confirmed as this sequenced loci also known as rml-2 Curator_confirmed: WBPerson1983
  Method: Gene