WormBase Tree Display for Gene: WBGene00022603

WBGene00022603 SMap: S_parent: Sequence: ZC404
  Identity: Version: 2
    Name: CGC_name: gck-2 Person_evidence: WBPerson1068
      Sequence_name: ZC404.9
      Molecular_name: ZC404.9
        ZC404.9.1
        CE07599
      Other_name: CELE_ZC404.9 Accession_evidence: NDB BX284605
      Public_name: gck-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:06 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 28 Jan 2005 10:28:25 WBPerson2970 Name_change: CGC_name: gck-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gck
    Allele (80)
    Possibly_affected_by: WBVar02152831
    Strain: WBStrain00002830
      WBStrain00037131
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (47)
    Paralog (27)
    Structured_description: Automated_description: Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. Expressed in several structures, including embryonic cell and vulval precursor cell. Used to study ciliopathy. Is an ortholog of human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3) and MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0060340 Homo sapiens Paper_evidence: WBPaper00053642
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 Mar 2019 00:00:00
  Models_disease_asserted: WBDOannot00000649
  Molecular_info: Corresponding_CDS: ZC404.9
    Corresponding_transcript: ZC404.9.1
    Other_sequence (37)
    Associated_feature: WBsf669076
      WBsf669077
      WBsf233868
      WBsf233869
      WBsf233870
      WBsf233871
      WBsf233872
  Experimental_info: RNAi_result: WBRNAi00038041 Inferred_automatically: RNAi_primary
      WBRNAi00058891 Inferred_automatically: RNAi_primary
      WBRNAi00101961 Inferred_automatically: RNAi_primary
      WBRNAi00021674 Inferred_automatically: RNAi_primary
      WBRNAi00021680 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram863
      Chronogram1791
      Expr7168
      Expr14760
      Expr1028183
      Expr1039984
      Expr1162327
      Expr2011963
      Expr2030200
    Drives_construct: WBCnstr00002279
      WBCnstr00004287
      WBCnstr00024119
    Construct_product: WBCnstr00024119
    Microarray_results (18)
    Expression_cluster: WBPaper00029359_1197
      WBPaper00029359_1225
      WBPaper00029359_1291
      WBPaper00029359_1367
      WBPaper00029359_1483
      WBPaper00029359_1494
      WBPaper00029359_1546
      WBPaper00029359_1561
      WBPaper00029359_1655
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00048762:FOG-3_associated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_L4
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00054792:FOG-3_interacting
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061527:lst-4_22151-F46F11.6_12556
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_10
      cgc4489_group_18
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037147:heatshock_upregulated
      WBPaper00037611:RNP-8-associated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      [cgc6390]:Cluster_F
      [cgc6390]:intrinsic
    Interaction (26)
  Map_info (3)
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene