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WormBase Tree Display for Gene: WBGene00016990

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Name Class

WBGene00016990SMapS_parentSequenceCD4
IdentityVersion2
NameCGC_namevps-37Person_evidenceWBPerson3188
Sequence_nameCD4.4
Molecular_nameCD4.4
CD4.4.1
CE16952
Other_nameCELE_CD4.4Accession_evidenceNDBBX284605
Public_namevps-37
DB_infoDatabaseAceViewgene5G71
WormQTLgeneWBGene00016990
WormFluxgeneWBGene00016990
NDBlocus_tagCELE_CD4.4
PanthergeneCAEEL|WormBase=WBGene00016990|UniProtKB=O44158
familyPTHR13678
NCBIgene178944
RefSeqproteinNM_072073.5
TREEFAMTREEFAM_IDTF321840
TrEMBLUniProtAccO44158
UniProt_GCRPUniProtAccO44158
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:58WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
210 Sep 2007 09:52:01WBPerson2970Name_changeCGC_namevps-37
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classvps
Allele (15)
StrainWBStrain00002948
WBStrain00036336
RNASeq_FPKM (74)
GO_annotation (14)
Contained_in_operonCEOP5076
Ortholog (44)
Structured_descriptionConcise_descriptionvps-37 encodes the C. elegans ortholog of Saccharomyces cerevisiae Srn2p/Vps37p, a member of the endosomal sorting ESCRT-I complex that functions in endosomal sorting of mono-ubiquitinated membrane proteins; in C. elegans, VPS-37 is an essential component of the ESCRT-I complex (other members include VPS-28, MVB-12, and TSG-101) that affects the rate at which cell surface receptors are degraded and hence, the rate at which their activity is downregulated; a VPS-37::GFP fusion protein localizes to the cytosol and to endosomal membranes.Paper_evidenceWBPaper00031035
Curator_confirmedWBPerson1843
Date_last_updated09 Jul 2010 00:00:00
Automated_descriptionInvolved in receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Is an ortholog of human VPS37B (VPS37B subunit of ESCRT-I).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_info (4)
Experimental_infoRNAi_result (60)
Expr_patternExpr5605
Expr1018249
Expr1037296
Expr1147284
Expr2018028
Expr2036165
Drives_constructWBCnstr00003454
WBCnstr00027652
Construct_productWBCnstr00000920
WBCnstr00027652
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032097:CGH-1-associated-mRNA
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:hypodermis_larva_enriched
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046858:elt-2(RNAi)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051021:4-bromodiphenyl-ether_downregulated
WBPaper00051039:germline_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00061340:SIB
WBPaper00061527:pch-2-B0393.3
WBPaper00061651:VB01_enriched
WBPaper00061902:CAMT-1_interacting
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_5_3
cgc4489_group_1
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00032165:differentially_expressed_with_age_medoid_7
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_B
WBPaper00037113:Diazinon_16C_regulated
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040963:TA100_down
WBPaper00040963:TA300_down
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:0.1mM-paraquat_upregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MD_pd(41_min)
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_ME
[cgc6390]:Cluster_F
Interaction (36)
Map_infoMapVPosition-1.37551Error0.00596
PositivePositive_cloneCD4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027740
WBPaper00031035
WBPaper00031212
WBPaper00031867
WBPaper00038491
WBPaper00038585
WBPaper00039823
WBPaper00055090
WBPaper00064078
WBPaper00064325
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene