Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00015248

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00015248SMapS_parentSequenceB0546
IdentityVersion2
NameCGC_namemai-2Person_evidenceWBPerson71
Sequence_nameB0546.1
Molecular_nameB0546.1
B0546.1.1
CE16792
Other_name4E151Accession_evidenceEMBLAF326939
CELE_B0546.1Accession_evidenceNDBBX284604
Public_namemai-2
DB_infoDatabaseAceViewgene4E151
WormQTLgeneWBGene00015248
WormFluxgeneWBGene00015248
NDBlocus_tagCELE_B0546.1
PanthergeneCAEEL|WormBase=WBGene00015248|UniProtKB=O44441
familyPTHR23407
NCBIgene177106
RefSeqproteinNM_067935.9
SwissProtUniProtAccO44441
TREEFAMTREEFAM_IDTF320659
UniProt_GCRPUniProtAccO44441
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:55WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
213 Oct 2006 11:22:39WBPerson2970Name_changeCGC_namemai-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmai
Allele (20)
Possibly_affected_byWBVar02158609
WBVar02158610
StrainWBStrain00002870
WBStrain00052821
WBStrain00052822
WBStrain00052826
WBStrain00052827
WBStrain00052828
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (39)
Paralog (2)
Structured_descriptionConcise_descriptionmai-2/B0546.1 is orthologous to mitochondrial intrinsic ATPase inhibitorprotein (IF(1)), which blocks reverse action (ATP hydrolysis) byF(0)F(1)-ATPase when its (normally required) proton gradient is lost;MAI-2 has a mitochondrial import signal at its N-terminus, and istransported to yeast mitochondria; MAI-2 can inhibit yeastF(0)F(1)-ATPase, and this inhibition is pH-dependent; MAI-2's tertiarystructure is dominated by beta-strands and random loops.Paper_evidenceWBPaper00028361
Curator_confirmedWBPerson567
Date_last_updated12 Oct 2006 00:00:00
Automated_descriptionEnables ATPase inhibitor activity. Predicted to be involved in heme biosynthetic process. Located in mitochondrion. Expressed in germ line and tail. Is an ortholog of human ATP5IF1 (ATP synthase inhibitory factor subunit 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSB0546.1
Corresponding_transcriptB0546.1.1
Other_sequence (84)
Associated_featureWBsf645870
WBsf645871
WBsf981718
WBsf995950
WBsf995951
WBsf1017070
WBsf1017071
WBsf228096
Experimental_infoRNAi_resultWBRNAi00039181Inferred_automaticallyRNAi_primary
WBRNAi00033357Inferred_automaticallyRNAi_primary
WBRNAi00009847Inferred_automaticallyRNAi_primary
Expr_patternChronogram1709
Expr5085
Expr13497
Expr1015246
Expr1036531
Expr1143326
Expr2013357
Expr2031589
Drives_constructWBCnstr00003390
WBCnstr00039554
WBCnstr00042804
WBCnstr00042805
Construct_productWBCnstr00039554
Microarray_results (23)
Expression_clusterWBPaper00029359_1217
WBPaper00029359_1280
WBPaper00029359_1353
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1548
WBPaper00029359_1604
WBPaper00032425:up_in_alg-1
WBPaper00032425:up_in_rde-4
WBPaper00032425:up_in_zfp-1
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033444:BacteriaDiet_regulated
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_downregulated
WBPaper00038118:stress_downregulated_N2
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040965:lipid-droplet_associated_protein
WBPaper00044128:daf-2(e1370)_upregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00046303:P.aeruginosa_downregulated_protein
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049018:ham-3(RNAi)_downregulated
WBPaper00049018:swsn-2.2(RNAi)_downregulated
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050412:cco-1(RNAi)_downregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051265:F4_morc-1(tm6048)_downregulated
WBPaper00051538:micro-gavity_downregulated_protein
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053289:DREAM-target
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00054410:set-26(tm2467)_downregulated
WBPaper00054996:activated_sperm_CE
WBPaper00054996:membranous_oraganelle_CE
WBPaper00054996:unactivated_spermatid_CE
WBPaper00055049:S.gordonii_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057288:Cold_upregulated_transcript
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061527:C18E9.4-T27E9.2
WBPaper00061527:F45H10.2-R53.4_21676
WBPaper00061651:Distal_tip_cell_enriched
WBPaper00061818:AFD_enriched_protein
WBPaper00061818:ELKS-1_interacting
WBPaper00061902:CAMT-1_interacting
WBPaper00062143:PQN-59_interacting
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00063930:BRD-1_interacting
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065120:body-muscle-transcriptome
WBPaper00025032:cluster_171
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026629:L2_male_enriched
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026952:class_A
WBPaper00026980:intestine_enriched
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031832:slr-2_regulated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
WBPaper00057098:SiO2-nanoparticles_downregulated
[cgc5767]:cluster_3
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(66_min)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
Interaction (22)
Map_infoMapIVPosition-4.55224Error0.010154
PositivePositive_cloneB0546Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00028361
WBPaper00038491
WBPaper00043855
WBPaper00052941
WBPaper00055090
WBPaper00061615
WBPaper00062370
WBPaper00064661
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene