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WormBase Tree Display for Gene: WBGene00011938

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Name Class

WBGene00011938SMapS_parentSequenceT22H6
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classalh
Allele (61)
StrainWBStrain00001713
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (35)
Structured_descriptionAutomated_descriptionPredicted to enable glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process and phosphorylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Is an ortholog of human ALDH18A1 (aldehyde dehydrogenase 18 family member A1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (8)
Molecular_infoCorresponding_CDST22H6.2a
T22H6.2b
Corresponding_CDS_historyT22H6.2:wp42
Corresponding_transcriptT22H6.2a.1
T22H6.2b.1
Other_sequence (56)
Associated_featureWBsf648627
WBsf663444
WBsf663445
WBsf663446
WBsf663447
WBsf1007420
WBsf236510
Experimental_infoRNAi_resultWBRNAi00096926Inferred_automaticallyRNAi_primary
WBRNAi00090699Inferred_automaticallyRNAi_primary
WBRNAi00096927Inferred_automaticallyRNAi_primary
WBRNAi00053869Inferred_automaticallyRNAi_primary
WBRNAi00035830Inferred_automaticallyRNAi_primary
WBRNAi00096986Inferred_automaticallyRNAi_primary
WBRNAi00009210Inferred_automaticallyRNAi_primary
WBRNAi00026362Inferred_automaticallyRNAi_primary
WBRNAi00071636Inferred_automaticallyRNAi_primary
Expr_patternExpr6745
Expr1024987
Expr1035269
Expr1157418
Expr2009302
Expr2027539
Drives_constructWBCnstr00002537
WBCnstr00030267
Construct_productWBCnstr00030267
Microarray_results (25)
Expression_clusterWBPaper00028451:Abundant_spermatogenesis_enriched
WBPaper00032976:non_compensated_genes
WBPaper00035073:mitochondria_protein
WBPaper00038168:lin-35_downregulated
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044037:eat-2_downregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:oscillating_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045050:csr-1(hypomorph)_downregulated
WBPaper00045390:ubc-9(RNAi)_upregulated
WBPaper00045417:128Q-huntingtin_upreglated
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00046121:endoderm_unique
WBPaper00046303:P.aeruginosa_upregulated_protein
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
WBPaper00048910:mRNA-interacting_protein
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_upregulated
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050599:nicotine(0.01mM)_upregulated
WBPaper00050698:DEP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051305:vit-2(ac3)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053402:cco-1(RNAi)_downregulated
WBPaper00053615:SMO-1_target
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_upregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L3
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056330:glycine_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
WBPaper00056826:SGP_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00056997:NMAD-1_interacting
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058711:wdr-5(ok1417)_upregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059231:alh-6(lax105)_L4_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059605:MUT-16_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_downregulated_L1
WBPaper00059739:hira-1(gk835598)_downregulated_L4
WBPaper00059839:S.maltophilia_regulated
WBPaper00059987:Wounding_upregulated
WBPaper00060084:cco-1(RNAi)_downregulated_N2
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060445:nfki-1(cer1)_upregulated_L1
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060764:swsn-1(os22ts)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061340:Intestine
WBPaper00061377:MYRF-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061466:nath-10(icb99)_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:mlt-9_22518-F33D4.6_14044
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062143:PQN-59_interacting
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062520:qui-1(db104)_upregulated
WBPaper00062534:fat-P-80_downregulated
WBPaper00062554:MAGU-2_interacting
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_downregulated
WBPaper00064201:SNA-3_interacting
WBPaper00064539:nhr-114(gk849)_downregulated
WBPaper00064632:daf-2(e1370)_upregulated_intestine
WBPaper00064716:paraquat_downregulated
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064789:Day6_vs_Day1_downregulated_neuron
WBPaper00064952:Day5_vs_L4_downregulated_20C
WBPaper00064952:Day5_vs_L4_downregulated_25C
WBPaper00064952:Day10_vs_L4_downregulated_20C
WBPaper00064952:Day10_vs_L4_downregulated_25C
WBPaper00065074:glna(-)_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4386_cluster_2_4
cgc4489_group_8
WBPaper00025032:cluster_23
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026952:class_E
WBPaper00026980:intestine_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032948:FedUp
WBPaper00032948:MoltOssilate
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00038172:crh-1null_down_regulated
WBPaper00038172:tax-6null_down_regulated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00038304:octr-1_regulated
WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040963:Q50_up
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041174:environmental
WBPaper00041174:genotypic
WBPaper00041174:genotypic_and_environmental
WBPaper00041207:CE_dauer_down
WBPaper00041211:RPW-24_Down
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:jun-1_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042204:Comamonas_DA1877_downregulated
WBPaper00042258:DA1877_downregulated_GravidAdult
WBPaper00042258:DA1877_downregulated_YoungAdult
WBPaper00044091:Bpseudomallei_induced_2h
WBPaper00044091:Bpseudomallei_induced_4h
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00044535:male_downregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00046083:oga-1(ok1207)_OP50_downregulated
WBPaper00046083:pmk-1(km25)_OP50_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00050538:Fasting_upregulated
WBPaper00053550:daf-19(m86)_downregulated_AdultDay2
[cgc5767]:cluster_4
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(83_min)
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_SE
[cgc5767]:expression_class_SET
[cgc5767]:expression_class_SE_pi(53_min)
[cgc6390]:Cluster_C
Interaction (78)
Map_infoMapXPosition8.39739
PositivePositive_cloneT22H6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00038341
WBPaper00038491
WBPaper00040958
WBPaper00042257
WBPaper00049828
WBPaper00055090
WBPaper00061842
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene