WormBase Tree Display for Gene: WBGene00010769

WBGene00010769 SMap: S_parent: Sequence: K11D2
  Identity: Version: 2
    Name: CGC_name: asah-1
      Sequence_name: K11D2.2
      Molecular_name: K11D2.2
        K11D2.2.1
        CE12120
      Other_name: dod-7 CGC_data_submission
        CELE_K11D2.2 Accession_evidence: NDB BX284601
      Public_name: asah-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 25 Aug 2004 14:17:26 WBPerson1971 Name_change: CGC_name: asah-1
                Other_name: dod-7
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: asah
    Allele (54)
    Strain: WBStrain00033927
      WBStrain00055428
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (39)
    Paralog: WBGene00009192 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021917 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in fatty acid metabolic process and sphingolipid metabolic process. Predicted to be located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Is an ortholog of human ASAH1 (N-acylsphingosine amidohydrolase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (3)
  Molecular_info: Corresponding_CDS: K11D2.2
    Corresponding_transcript: K11D2.2.1
    Other_sequence (52)
    Associated_feature: WBsf643764
      WBsf985584
      WBsf218603
      WBsf218604
  Experimental_info: RNAi_result: WBRNAi00034283 Inferred_automatically: RNAi_primary
      WBRNAi00063174 Inferred_automatically: RNAi_primary
      WBRNAi00090564 Inferred_automatically: RNAi_primary
      WBRNAi00001097 Inferred_automatically: RNAi_primary
      WBRNAi00003984 Inferred_automatically: RNAi_primary
      WBRNAi00050596 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00001079
      WBCnstr00002691
      WBCnstr00004394
      WBCnstr00011665
      WBCnstr00043068
    Microarray_results (20)
    Expression_cluster: WBPaper00028802:intestine_unique
      WBPaper00029359_1124
      WBPaper00029359_1141
      WBPaper00029359_1280
      WBPaper00029359_1304
      WBPaper00029359_1351
      WBPaper00029359_1444
      WBPaper00029359_1497
      WBPaper00029359_1504
      WBPaper00029359_1525
      WBPaper00029359_1604
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046128:ethanol_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046858:elt-2(RNAi)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048530:fshr-1(ok778)_PA14_upregulated
      WBPaper00048530:fshr-1(ok778)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049266:NaAsO2-Stress_regulated_N2
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049498:npr-1(ur89)_regulated_7
      WBPaper00049594:osm-9(ok1677)_NaCl(200mM)_upregulate
      WBPaper00049594:osm-9(ok1677)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053368:F.oxysporum_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:hif-1(ia4)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056165:mina-1(ok1521)_downregulated_transcript
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_20C
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
      WBPaper00057162:meg-3_meg-4_downregulated_sRNA
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:M.braciatum_upregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061340:ALM_PLM
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:asah-1-asm-2
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00064841:tent-5(tm3504)_downregulated_transcript
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:AFD_depleted
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065392:Lb.plantarum_upregulated
      WBPaper00065392:Lb.reuteri_upregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:13_1
      WBPaper00065849:ursolic-acid_regulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_1_1
      cgc4489_group_2
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00025099:MA_specific
      WBPaper00026980:intestine_enriched
      WBPaper00027342:alpha-Synuclein(A53T)_downregulated
      WBPaper00027342:alpha-Synuclein(WT)_downregulated
      WBPaper00029437:dcr-1_downregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:A_to_C_transit_decreased
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00032948:StarveUp2
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00035892:KIM5_vs_OP50_Up
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_G
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00040184:hcf-1down_sir-2.1up_daf-2nc
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042204:Comamonas_DA1877_upregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042258:DA1877_upregulated_YoungAdult
      WBPaper00044091:Bpseudomallei_repressed_4h
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045437:Toxic-Se_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_AdultDay2
      [cgc5976]:class_1
    Interaction (25)
  Map_info: Map: I Position: 13.2437 Error: 0.0148
    Positive: Positive_clone: K11D2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5396
    Pseudo_map_position
  Reference: WBPaper00005976
    WBPaper00038491
    WBPaper00041771
    WBPaper00042257
    WBPaper00055090
    WBPaper00065215
    WBPaper00065849
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene