WormBase Tree Display for Gene: WBGene00010498

WBGene00010498 SMap: S_parent: Sequence: K02B12
  Identity: Version: 2
    Name: CGC_name: tnsl-1
      Sequence_name: K02B12.5
      Molecular_name: K02B12.5
        K02B12.5.1
        CE53745
      Other_name: CELE_K02B12.5 Accession_evidence: NDB BX284601
      Public_name: tnsl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 13 Mar 2019 16:38:49 WBPerson1983 Name_change: CGC_name: tnsl-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tnsl
    Allele (98)
    RNASeq_FPKM (74)
    Contained_in_operon: CEOP1480
    Ortholog (26)
    Paralog: WBGene00001495 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Automated_description: Enriched in several structures, including Z1.p; body wall muscle cell; germ line; germline precursor cell; and male distal tip cell based on tiling array; RNA-seq; and microarray studies. Is affected by several genes including skn-1; daf-12; and hsf-1 based on tiling array; RNA-seq; and microarray studies. Is affected by thirteen chemicals including aldicarb; rotenone; and D-glucose based on microarray and RNA-seq studies. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Human TONSL enables histone binding activity and histone reader activity. Is predicted to encode a protein with the following domains: Ankyrin repeats (3 copies); Ankyrin repeat; Ankyrin repeats (many copies); Leucine-rich repeat domain superfamily; Ankyrin repeat-containing domain superfamily; Tetratricopeptide-like helical domain superfamily; Putative ankyrin repeat domain-containing protein 31; and Phosphorylation site. Is an ortholog of human TONSL (tonsoku like, DNA repair protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:5684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7801)
  Molecular_info: Corresponding_CDS: K02B12.5
    Corresponding_CDS_history: K02B12.5:wp106
      K02B12.5:wp151
      K02B12.5:wp273
    Corresponding_transcript: K02B12.5.1
    Associated_feature: WBsf664571
      WBsf984455
      WBsf1010248
      WBsf219936
  Experimental_info: RNAi_result: WBRNAi00060445 Inferred_automatically: RNAi_primary
      WBRNAi00060447 Inferred_automatically: RNAi_primary
      WBRNAi00060446 Inferred_automatically: RNAi_primary
      WBRNAi00116965 Inferred_automatically: RNAi_primary
      WBRNAi00049663 Inferred_automatically: RNAi_primary
      WBRNAi00049665 Inferred_automatically: RNAi_primary
      WBRNAi00002397 Inferred_automatically: RNAi_primary
      WBRNAi00003894 Inferred_automatically: RNAi_primary
      WBRNAi00060448 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025676
      Expr1034587
      Expr1153390
      Expr2004668
      Expr2022895
    Drives_construct: WBCnstr00031374
    Construct_product: WBCnstr00031374
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:ima-1_20458-bath-41
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_B
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053688:E.faecium_upregulated
      [cgc5767]:cluster_8
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(41_min)
      [cgc5767]:expression_class_E_pi(41_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction: WBInteraction000450001
  Map_info: Map: I Position: 2.89794
    Positive: Positive_clone: K02B12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene