otpl-8 encodes an ortholog of otopetrins such as human OTOP1 (OMIM:607806), OTOP2 (OMIM:607827), and OTOP3 (OMIM:607828), along with other homologs in fish and insects (such as crustacean OTOPLb); otopetrins are predicted to have 12 transmembrane helices; by homology with OTOP1 and OTOPLb, OTPL-8 might regulate intracellular calcium fluxes during extracellular stimuli, promote extracellular calcium carbonate biomineralization, or both; OTPL-8's paralogs include OTPL-1 through OTPL-7; OTPL-8 has no function in mass RNAi assays.
Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Is an ortholog of human OTOP1 (otopetrin 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.