WormBase Tree Display for Gene: WBGene00018478

WBGene00018478 SMap: S_parent: Sequence: F45F2
  Identity: Version: 2
    Name: CGC_name: otpl-5
      Sequence_name: F45F2.5
      Molecular_name: F45F2.5
        F45F2.5.1
        CE45695
      Other_name: CELE_F45F2.5 Accession_evidence: NDB BX284605
      Public_name: otpl-5
    DB_info: Database: AceView gene 5J11
        WormQTL gene WBGene00018478
        WormFlux gene WBGene00018478
        NDB locus_tag CELE_F45F2.5
        Panther gene CAEEL|WormBase=WBGene00018478|UniProtKB=G4SFC1
          family PTHR21522
        NCBI gene 185806
        RefSeq protein NM_072795.4
        TREEFAM TREEFAM_ID TF313428
        TrEMBL UniProtAcc G4SFC1
        UniProt_GCRP UniProtAcc G4SFC1
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 07 Apr 2008 11:28:34 WBPerson2970 Name_change: CGC_name: otpl-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: otpl
    Allele (41)
    Strain: WBStrain00050996
      WBStrain00055623
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (24)
    Paralog: WBGene00010403 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015035 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017034 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00017449 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00018477 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00018479 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00018480 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: otpl-5 encodes an ortholog of otopetrins such as human OTOP1 (OMIM:607806), OTOP2 (OMIM:607827), and OTOP3 (OMIM:607828), along with other homologs in fish and insects (such as crustacean OTOPLb); otopetrins are predicted to have 12 transmembrane helices; by homology with OTOP1 and OTOPLb, OTPL-5 might regulate intracellular calcium fluxes during extracellular stimuli, promote extracellular calcium carbonate biomineralization, or both; OTPL-5's paralogs include OTPL-1 through OTPL-8; OTPL-5 has no function in mass RNAi assays. Paper_evidence: WBPaper00031620
            WBPaper00031621
            WBPaper00031622
            WBPaper00031623
          Curator_confirmed: WBPerson567
          Date_last_updated: 04 Apr 2008 00:00:00
      Automated_description: Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Is an ortholog of human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F45F2.5
    Corresponding_CDS_history: F45F2.5:wp218
    Corresponding_transcript: F45F2.5.1
  Experimental_info: RNAi_result: WBRNAi00015037 Inferred_automatically: RNAi_primary
      WBRNAi00047427 Inferred_automatically: RNAi_primary
      WBRNAi00032318 Inferred_automatically: RNAi_primary
      WBRNAi00103365 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012878
      Expr1151270
      Expr2014661
      Expr2032894
    Drives_construct: WBCnstr00026487
    Construct_product: WBCnstr00026487
    Microarray_results (16)
    Expression_cluster (40)
    Interaction (54)
  Map_info: Map: V Position: 1.4379 Error: 0.000586
    Positive: Positive_clone: F45F2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00031620
    WBPaper00031622
    WBPaper00038491
    WBPaper00055090
    WBPaper00056048
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene