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WormBase Tree Display for Gene: WBGene00008458

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Name Class

WBGene00008458SMapS_parentSequenceE02H1
Identity (6)
Gene_infoBiotypeSO:0001217
Allele (18)
StrainWBStrain00037116
RNASeq_FPKM (74)
GO_annotation (21)
Contained_in_operonCEOP2436
Ortholog (36)
ParalogWBGene00006391Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptionE02H1.6 encodes an ortholog of human TAF9 (OMIM:600822; also known asAK6, adrenal gland protein AD-004 like protein, ADLP) and of S.cerevisiae Fap7p; like its human ortholog, E02H1.6 is nuclear, and ispredicted to likewise be a TATA box binding protein (TBP)-associatedfactor mediating activation of RNA polymerase II; E02H1.6 prefers ATPand dATP as phosphate donors; E02H1.6's biochemical activity is unusual,since it also prefers AMP and dAMP as substrates, and tolerates CMP, TMPand shikimate acid as substrates as well; since yeast Fap7p promotespre-rRNA cleavage, E02H1.6 may be multifunctional; in RNAi assays,E02H1.6 is required for normally fast growth; E02H1.6 is coexpressedwith pme-2 in an operon, and thus, like PME-2, may function in DNArepair.Paper_evidenceWBPaper00005600
WBPaper00027687
WBPaper00028896
WBPaper00028897
WBPaper00028898
WBPaper00028899
Curator_confirmedWBPerson567
Date_last_updated20 Feb 2007 00:00:00
Automated_descriptionPredicted to enable ATP binding activity and adenylate kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation and phosphorylation. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human AK6 (adenylate kinase 6).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSE02H1.6
Corresponding_CDS_historyE02H1.6:wp54
Corresponding_transcriptE02H1.6.1
Other_sequence (35)
Associated_featureWBsf221907
Experimental_infoRNAi_resultWBRNAi00007974Inferred_automaticallyRNAi_primary
WBRNAi00012646Inferred_automaticallyRNAi_primary
WBRNAi00065873Inferred_automaticallyRNAi_primary
WBRNAi00043602Inferred_automaticallyRNAi_primary
WBRNAi00030468Inferred_automaticallyRNAi_primary
Expr_patternExpr4325
Expr1020050
Expr1033684
Expr1147592
Expr2002134
Expr2020357
Drives_constructWBCnstr00011923
WBCnstr00032949
Construct_productWBCnstr00011923
WBCnstr00032949
AntibodyWBAntibody00001104
Microarray_results (19)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032425:up_in_zfp-1
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00040221:DAF-12_target_ALF4
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00045729:gld-4(RNAi)_downregulated
WBPaper00045774:clk-1_downregulated
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:lpd-2-EEED8.16
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064716:paraquat_upregulated
WBPaper00065199:Transgeneration-starvation_regulated_fed
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065841:68_0
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_3_2
cgc4489_group_4
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031832:slr-2_regulated
WBPaper00032165:differentially_expressed_with_age_medoid_7
WBPaper00035905:FBF-1_Associated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5376]:let-60(G12V)-regulated_genes
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(122_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:intrinsic
Interaction (101)
Map_infoPositivePositive_cloneE02H1Inferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionII1.61605
ReferenceWBPaper00027687
WBPaper00038491
WBPaper00041771
WBPaper00055090
WBPaper00065308
MethodGene