WormBase Tree Display for Gene: WBGene00007577

WBGene00007577 SMap: S_parent: Sequence: C14B1
  Identity: Version: 2
    Name: CGC_name: nrde-1 Person_evidence: WBPerson5515
            WBPerson315
      Sequence_name: C14B1.6
      Molecular_name: C14B1.6a
        C14B1.6a.1
        CE31415
        C14B1.6b
        CE52454
        C14B1.6b.1
      Other_name: CELE_C14B1.6 Accession_evidence: NDB BX284603
      Public_name: nrde-1
    DB_info: Database: AceView gene 3E807
        WormQTL gene WBGene00007577
        WormFlux gene WBGene00007577
        NDB locus_tag CELE_C14B1.6
        NCBI gene 175477
        RefSeq protein NM_001361894.4
            NM_065351.8
        TrEMBL UniProtAcc Q17968
            A0A2K5ATT7
        UniProt_GCRP UniProtAcc Q17968
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 17 May 2011 14:01:04 WBPerson2970 Name_change: CGC_name: nrde-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nrde
    Allele (119)
    Strain: WBStrain00040757
    RNASeq_FPKM (74)
    GO_annotation: 00059813
      00059814
    Contained_in_operon: CEOP3136
    Ortholog (24)
    Structured_description: Concise_description: nrde-1 encodes a novel protein conserved amongst nematodes; NRDE-1 activity is required, along with that of NRDE-2, NRDE-3, and NRDE-4, for regulation of gene expression via a nuclear RNAi pathway that inhibits RNA polymerase II elongation and deposits histone H3K9 methylation on genomic regions targeted by RNAi; an NRDE-1:GFP fusion protein localizes to the nucleus. Paper_evidence: WBPaper00040168
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Sep 2011 00:00:00
      Automated_description: Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in nucleus. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS (2)
    Corresponding_CDS_history: C14B1.6:wp82
    Corresponding_transcript: C14B1.6a.1
      C14B1.6b.1
    Other_sequence: CRC07998_1
      CR04204
    Associated_feature: WBsf658767
      WBsf658768
      WBsf991880
      WBsf991881
      WBsf224647
  Experimental_info: RNAi_result: WBRNAi00010727 Inferred_automatically: RNAi_primary
      WBRNAi00067969 Inferred_automatically: RNAi_primary
      WBRNAi00067214 Inferred_automatically: RNAi_primary
      WBRNAi00040497 Inferred_automatically: RNAi_primary
      WBRNAi00040494 Inferred_automatically: RNAi_primary
      WBRNAi00006299 Inferred_automatically: RNAi_primary
      WBRNAi00010725 Inferred_automatically: RNAi_primary
      WBRNAi00006346 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9671
      Expr1024514
      Expr1033260
      Expr1144562
      Expr2014438
      Expr2032679
    Drives_construct: WBCnstr00033637
    Construct_product: WBCnstr00014214
      WBCnstr00033637
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:RIA_parent
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:kle-2_4298-vrk-1
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062456:doxycycline_downregulated_N2_protein
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00032948:StarveUp4
      WBPaper00036286:Pattern_B
      WBPaper00037695:LD_3-day
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00053688:E.faecium_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(186_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(66_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:herm_sex-enriched
      [cgc6390]:intrinsic
    Interaction: WBInteraction000363076
      WBInteraction000441362
      WBInteraction000570063
  Map_info: Map: III Position: -4.35611 Error: 0.037595
    Positive: Positive_clone: C14B1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene