WormBase Tree Display for Gene: WBGene00007488

WBGene00007488 SMap: S_parent: Sequence: C09G5
  Identity: Version: 2
    Name: CGC_name: dph-2 Person_evidence: WBPerson1847
      Sequence_name: C09G5.2
      Molecular_name: C09G5.2a
        C09G5.2a.1
        CE15608
        C09G5.2b
        CE45960
        C09G5.2b.1
      Other_name: CELE_C09G5.2 Accession_evidence: NDB BX284602
      Public_name: dph-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 08 Jan 2009 14:04:49 WBPerson2970 Name_change: CGC_name: dph-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dph
    Allele (181)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (57)
    Paralog: WBGene00007576 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: dph-2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); DPH-2 is a putative protein component of diphtamide synthesis. Paper_evidence: WBPaper00005654
            WBPaper00012895
            WBPaper00013419
            WBPaper00013534
            WBPaper00013537
            WBPaper00013539
            WBPaper00013556
            WBPaper00013562
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Dec 2009 00:00:00
      Automated_description: Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be located in protein-containing complex. Is an ortholog of human DPH2 (diphthamide biosynthesis 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070478 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3004)
  Molecular_info: Corresponding_CDS (2)
    Corresponding_transcript: C09G5.2a.1
      C09G5.2b.1
    Other_sequence: Acan_isotig11903
      JI174376.1
      CBC11879_1
      Oden_isotig23517
      Tcir_isotig13161
      FK807855.1
      Oden_isotig24927
    Associated_feature: WBsf989448
      WBsf989449
      WBsf1013074
      WBsf223828
  Experimental_info: RNAi_result: WBRNAi00028737 Inferred_automatically: RNAi_primary
      WBRNAi00040232 Inferred_automatically: RNAi_primary
      WBRNAi00075412 Inferred_automatically: RNAi_primary
      WBRNAi00072831 Inferred_automatically: RNAi_primary
      WBRNAi00072830 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012769
      Expr1033219
      Expr1144306
      Expr2011048
      Expr2029285
    Drives_construct: WBCnstr00033701
    Construct_product: WBCnstr00033701
    Microarray_results (21)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00044246:pgrn-1_ced-1_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045774:clk-1_downregulated_CoQ10_independent
      WBPaper00045971:tunicamycin_upregulated_control
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048579:aging_downregulated
      WBPaper00048988:daf-2(e1370)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:B
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:T02E1.2-uri-1
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062590:Aging_downregulated_body-wall-muscle
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_8
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_H
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(186_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_C
    Interaction (31)
  Map_info: Map: II Position: 3.12407 Error: 3.7e-05
    Positive: Positive_clone: C09G5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00062217
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene