WormBase Tree Display for Gene: WBGene00006981

WBGene00006981 SMap: S_parent: Sequence: C09C7
  Identity: Version: 1
    Name: CGC_name: zig-4 Person_evidence: WBPerson260
      Sequence_name: C09C7.1
      Molecular_name: C09C7.1
        C09C7.1.1
        CE02468
      Other_name: CELE_C09C7.1 Accession_evidence: NDB BX284606
      Public_name: zig-4
    DB_info: Database: AceView gene XI545
        WormQTL gene WBGene00006981
        WormFlux gene WBGene00006981
        NDB locus_tag CELE_C09C7.1
        NCBI gene 181051
        RefSeq protein NM_076934.7
        SwissProt UniProtAcc G5ECB1
        TREEFAM TREEFAM_ID TF343606
        UniProt_GCRP UniProtAcc G5ECB1
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:44 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zig
    Allele (33)
    Strain: WBStrain00029296
      WBStrain00001757
      WBStrain00029286
      WBStrain00035503
    RNASeq_FPKM (74)
    GO_annotation: 00011422
      00011423
      00011424
      00011425
    Ortholog (35)
    Paralog (24)
    Structured_description: Concise_description: zig-4 encodes a predicted secreted protein that is a member of the immunoglobulin superfamily of proteins; ZIG-4 activity is required for maintenance of ventral nerve cord organization: the AVKL/R and PVQL/R axons of the left and right ventral nerve cords do not maintain their proper spatial positions and drift into the opposite cord; a zig-4::gfp reporter fusion is expressed in the PVT, ASK, BAG, and M2 neurons, with expression also seen during the L1 stage in pharyngeal mesoderm and ectoderm. Paper_evidence: WBPaper00005064
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Jan 2008 00:00:00
      Automated_description: Involved in neuron development. Predicted to be located in extracellular region and plasma membrane. Expressed in neurons and pharynx. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C09C7.1
    Corresponding_transcript: C09C7.1.1
    Other_sequence: FD514513.1
      CJC10066_1
      CRC03657_1
      JI166385.1
      CR07197
    Associated_feature (3)
  Experimental_info: RNAi_result: WBRNAi00000560 Inferred_automatically: RNAi_primary
      WBRNAi00010516 Inferred_automatically: RNAi_primary
      WBRNAi00028715 Inferred_automatically: RNAi_primary
      WBRNAi00040171 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram267
      Expr1750
      Expr3881
      Expr5212
      Expr1011484
      Expr1032984
      Expr1144247
      Expr2018143
      Expr2036280
    Drives_construct (11)
    Construct_product: WBCnstr00006621
      WBCnstr00006622
      WBCnstr00006631
      WBCnstr00006632
      WBCnstr00034054
    Microarray_results (22)
    Expression_cluster: WBPaper00025192:hda-1(RNAi)_upregulated
      WBPaper00032976:dosage_compensated_genes
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045017:blmp-1(tm548)_upregulated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00046121:ecdoderm_unique
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050928:male-mating_downregulated
      WBPaper00050990:NMDA-neuron_enriched
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056039:hda-6(ok3203)_upregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-2(RNAi)_upregulated
      WBPaper00056284:ints-4(RNAi)_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:AFD
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:g1A_parent
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_ASG_AWA
      WBPaper00061340:Neuroblast_ASH_RIB
      WBPaper00061340:NSM_parent
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061651:AFD_enriched
      WBPaper00061651:AIM_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:BDU_enriched
      WBPaper00061651:LUA_enriched
      WBPaper00061651:PHC_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062103:neuron_enriched
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064762:freezing-thaw_regulated
      WBPaper00064788:ketamine_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065158:AFD_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:81
      WBPaper00065623:110
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:57_1
      WBPaper00065841:63_0
      WBPaper00065841:80_0
      WBPaper00065841:85_0
      WBPaper00065841:108_0
      WBPaper00065841:137_0
      WBPaper00065841:140_0
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript
      WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_13
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:FedUp
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037695:WC_5-day
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00039866:SAM_daf-19_upregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040876:mir-35_upregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (15)
    Anatomy_function: WBbtf0027
  Map_info: Map: X Position: -0.996305 Error: 0.016382
    Positive: Positive_clone: C09C7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4178
        4766
    Pseudo_map_position
  Reference (26)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene