WormBase Tree Display for Gene: WBGene00006732

WBGene00006732 SMap: S_parent: Sequence: F26H9
  Identity: Version: 1
    Name: CGC_name: uev-3 Person_evidence: WBPerson89
      Sequence_name: F26H9.7
      Molecular_name: F26H9.7a
        F26H9.7a.1
        CE53757
        F26H9.7b
        CE53712
        F26H9.7b.1
      Other_name: CELE_F26H9.7 Accession_evidence: NDB BX284601
      Public_name: uev-3
    DB_info: Database: AceView gene 1J887
        WormQTL gene WBGene00006732
        WormFlux gene WBGene00006732
        NDB locus_tag CELE_F26H9.7
        Panther gene CAEEL|WormBase=WBGene00006732|UniProtKB=P91853
          family PTHR24068
        NCBI gene 185003
        RefSeq protein NM_001375057.2
            NM_001375060.3
        SwissProt UniProtAcc P91853
        TrEMBL UniProtAcc A0A5K1ICF0
        UniProt_GCRP UniProtAcc P91853
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: uev
    Allele (37)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Contained_in_operon: CEOP1984
    Ortholog (19)
    Paralog: WBGene00006708 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: uev-3 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-3 in C. elegans development and/or behavior is not yet known; based on similarity to Saccharomyces cerevisiae and human proteins, however, UEV-3 may play a role in cell cycle control or response to stress or DNA damage. Paper_evidence: WBPaper00005337
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Predicted to be located in nucleus. Expressed in several structures, including ventral cord neurons. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F26H9.7a
      F26H9.7b
    Corresponding_CDS_history: F26H9.7:wp187
      F26H9.7:wp273
    Corresponding_transcript: F26H9.7a.1
      F26H9.7b.1
  Experimental_info: RNAi_result: WBRNAi00003492 Inferred_automatically: RNAi_primary
      WBRNAi00113114 Inferred_automatically: RNAi_primary
      WBRNAi00112992 Inferred_automatically: RNAi_primary
      WBRNAi00082822 Inferred_automatically: RNAi_primary
      WBRNAi00076352 Inferred_automatically: RNAi_primary
      WBRNAi00113222 Inferred_automatically: RNAi_primary
      WBRNAi00045710 Inferred_automatically: RNAi_primary
      WBRNAi00031479 Inferred_automatically: RNAi_primary
      WBRNAi00113162 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr12618
      Expr12619
      Expr12620
      Expr1018112
      Expr1032807
      Expr1149622
      Expr2017744
      Expr2035883
    Drives_construct: WBCnstr00034188
      WBCnstr00039338
    Construct_product: WBCnstr00022301
      WBCnstr00034188
      WBCnstr00039339
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035211:age-1_vs_age-1_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00056284:ints-11(RNAi)_upregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061340:M1_parent
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:NSM_parent
      WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:lpd-2-EEED8.16
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032948:StarveUp3
      WBPaper00034739:N2moreDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00036429:glp-1(oz112)_upregulated
      WBPaper00037695:LD_3-day
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (17)
    WBProcess: WBbiopr:00000117
  Map_info: Map: I Position: 3.73901 Error: 0.001658
    Positive: Positive_clone: F26H9 Inferred_automatically (2)
    Pseudo_map_position
  Reference: WBPaper00005337
    WBPaper00030342
    WBPaper00032678
    WBPaper00033175
    WBPaper00033359
    WBPaper00036408
    WBPaper00047284
    WBPaper00048972
    WBPaper00064297
  Remark: Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene