WormBase Tree Display for Gene: WBGene00006491

WBGene00006491 SMap: S_parent: Sequence: ZK809
  Identity: Version: 2
    Name: CGC_name: acl-3 Person_evidence: WBPerson1105
      Sequence_name: ZK809.2
      Molecular_name: ZK809.2
        ZK809.2.1
        CE46102
      Other_name: tag-145
        CELE_ZK809.2 Accession_evidence: NDB BX284604
      Public_name: acl-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Jul 2004 16:55:44 WBPerson1971 Name_change: CGC_name: acl-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acl
    Allele (18)
    Strain: WBStrain00035829
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (38)
    Structured_description: Concise_description: acl-3 encodes a glycerol-3-phosphate acyltransferase that is orthologous to human tafazzin (TAZ; OMIM:300394, mutated in Barth syndrome); by homology, ACL-3 is predicted to be a mitochondrial protein that plays a role in triacylglycerol metabolism; acl-3 expression shows some degree of dauer-specific induction. Paper_evidence: WBPaper00004103
            WBPaper00005654
            WBPaper00024497
            WBPaper00025054
            WBPaper00032488
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 22 Mar 2013 00:00:00
      Automated_description: Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and inner mitochondrial membrane organization. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Is an ortholog of human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050476 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11577)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11577)
  Molecular_info: Corresponding_CDS: ZK809.2
    Corresponding_CDS_history: ZK809.2:wp225
    Corresponding_transcript: ZK809.2.1
    Other_sequence (17)
    Associated_feature (5)
  Experimental_info: RNAi_result: WBRNAi00059726 Inferred_automatically: RNAi_primary
      WBRNAi00062499 Inferred_automatically: RNAi_primary
      WBRNAi00022172 Inferred_automatically: RNAi_primary
      WBRNAi00038443 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1010803
      Expr1032654
      Expr1163147
      Expr2009154
      Expr2027391
    Drives_construct: WBCnstr00034339
    Construct_product: WBCnstr00034339
    Microarray_results (21)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_OligoArray_24h
      WBPaper00032097:CGH-1-associated-mRNA
      WBPaper00035073:mitochondria_protein
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049954:BPA_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00060006:nfyb-1(cu13)_downregulated_transcript
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060911:prx-5(RNAi)_upregulated_protein
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061274:hypergravity_10xg_upregulated
      WBPaper00061340:g1A
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:pbs-3_18439-rpn-5
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_3
      WBPaper00025032:cluster_8
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (36)
  Map_info: Map: IV Position: 5.10764 Error: 0.005571
    Positive: Positive_clone: ZK809 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4270
        4289
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042257
    WBPaper00055090
    WBPaper00056678
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene