nck-1 encodes an SH2/SH3 domain-containing protein orthologous to the human NCK adaptor proteins that link tyrosine kinase signaling to actin cytoskeleton reorganization; in C. elegans, nck-1 activity is required for excretory canal migration and full axon migration in mechanosensory neurons; a nck-1::gfp promoter fusion is expressed in the excretory cell and ventral cord motorneurons.
Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. Located in cytoplasm and nucleus. Expressed in several structures, including egg-laying apparatus; gonad; hypodermis; neuroblasts; and neurons. Is an ortholog of human NCK1 (NCK adaptor protein 1) and NCK2 (NCK adaptor protein 2).