| WBGene00004988 | SMap | S_parent | Sequence | T08A9 |
|---|
| Identity | Version | 1 |
| | Name (5) |
| | DB_info | Database | AceView | gene | XH934 |
| | | | WormQTL | gene | WBGene00004988 |
| | | | WormFlux | gene | WBGene00004988 |
| | | | NDB | locus_tag | CELE_T08A9.7 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004988|UniProtKB=Q22336 |
| | | | | family | PTHR21579 |
| | | | NCBI | gene | 180993 |
| | | | RefSeq | protein | NM_076834.8 |
| | | | TREEFAM | TREEFAM_ID | TF343148 |
| | | | TrEMBL | UniProtAcc | Q22336 |
| | | | UniProt_GCRP | UniProtAcc | Q22336 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | spp |
| | Allele (14) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00074946 |
| | | 00074947 |
| | | 00074948 |
| | | 00074949 |
| | | 00074950 |
| | Ortholog (25) |
| | Paralog (12) |
| | Structured_description | Concise_description | spp-3 encodes an antimicrobial peptide that belongs to the SPP-protein family, called caenopores, with structural similarity to saposin-like proteins (SAPLIPs), the amoebapores and the mammalian NK-lysin and granulysin; caenopores are part of the worm's innate immune system and interact with and eliminate bacteria via membrane pore-forming activity; C. elegans has at least 33 putative SPP proteins; in an heterologous expression system, spp-3 formed pores in liposomes, and showed antimicrobial activity against several gram- negative and positive bacteria such as E. coli, P. aeruginosa, Ph. luminescence, X. nematophila, Y. enterocolitica, B. megaterium and B. thuringiensis; spp-3 is expressed in the intestine and the SDQR head neuron. | Paper_evidence | WBPaper00041167 |
| | | | | | WBPaper00035289 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 17 Sep 2013 00:00:00 |
| | | Automated_description | Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in protein-containing complex. Expressed in SDQR. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T08A9.7 |
| | Corresponding_transcript | T08A9.7.1 |
| | Other_sequence | CRC07887_1 |
| | | CBC05377_1 |
| | | CR08323 |
| | | CJC04748_1 |
| | Associated_feature | WBsf899530 | Paper_evidence | WBPaper00041167 |
| | | WBsf899531 | Paper_evidence | WBPaper00041167 |
| | | WBsf899532 | Paper_evidence | WBPaper00041167 |
| | | WBsf899533 | Paper_evidence | WBPaper00041167 |
| | | WBsf1005803 |
| | | WBsf1005804 |
| | | WBsf1005805 |
| | | WBsf1023225 |
| | | WBsf237567 |
| Experimental_info | RNAi_result | WBRNAi00082192 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00052828 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00092241 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082199 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr10056 |
| | | Expr1028065 |
| | | Expr1156430 |
| | | Expr2016081 |
| | | Expr2034317 |
| | Drives_construct | WBCnstr00015028 |
| | | WBCnstr00035289 |
| | Construct_product | WBCnstr00015028 |
| | | WBCnstr00035289 |
| | Microarray_results (17) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037624:ets-4(ok165)_downregulated |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_embryo_enriched |
| | | WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00038118:aak-2(gt33)_downregulated |
| | | WBPaper00038118:stress_downregulated_N2 |
| | | WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY18 |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045842:elt-2_dependent_hypoxia_upregulated |
| | | WBPaper00046496:Rifampicin_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049484:elt-2(RNAi)_downregulated_L1 |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050234:lin-28(RNAi)_downregulated |
| | | WBPaper00050332:daf-16(RNAi)_downregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051305:vit-2(ac3)_downregulated |
| | | WBPaper00051388:Glucose-diet_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053092:procyanidins_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_downregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053792:Ochrobactrum_upregulated |
| | | WBPaper00053814:OP50_vs_PY79_downregulated_PY79 |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:gut-microbiota_upregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059604:fluvastatin_upregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_upregulated_N2 |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060683:hlh-11(overexpression)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061007:M.braciatum_upregulated |
| | | WBPaper00061274:hypergravity_15xg_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_downregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062056:lin-35(n745)_downregulated |
| | | WBPaper00062118:neural-HSF-1_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00064005:starvation_upregulated_N2_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA |
| | | WBPaper00064473:ets-4(rrr16)_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064788:ketamine_upregulated |
| | | WBPaper00064841:tent-5(tm3504)_downregulated_transcript |
| | | WBPaper00064933:L1_secret_protein |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal |
| | | WBPaper00065215:microgravity_downregulated_DESeq2 |
| | | WBPaper00065392:Lb.delbrueckii_downregulated |
| | | WBPaper00065392:Lb.gasseri_downregulated |
| | | WBPaper00065392:Lb.reuteri_downregulated |
| | | WBPaper00065734:unc-25(e156)_upregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:3_0 |
| | | WBPaper00065841:3_1 |
| | | WBPaper00065841:3_2 |
| | | WBPaper00065841:3_5 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_OP50 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_PA14 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4386_cluster_1_2 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00028482:PA14_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00035892:Y.pestis_regulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5 |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed |
| | | WBPaper00044091:Bpseudomallei_repressed_8h |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (257) |
| Map_info | Map | X | Position | -1.7753 |
| | Positive | Positive_clone | T08A9 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00003435 |
| | WBPaper00006437 |
| | WBPaper00024209 |
| | WBPaper00027295 |
| | WBPaper00028482 |
| | WBPaper00035289 |
| | WBPaper00041167 |
| | WBPaper00064841 |
| | WBPaper00065877 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
