WormBase Tree Display for Gene: WBGene00004447

WBGene00004447 SMap: S_parent: Sequence: F10E7
  Identity: Version: 1
    Name (5)
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rpl
    Allele (14)
    Legacy_information: Orthologous to yeast (S.cerevisiae) ribosomal protein rpl33 using blastP
    RNASeq_FPKM (73)
    GO_annotation: 00047082
      00047083
      00047084
      00047085
      00047086
      00047087
      00047088
      00112899
      00112900
      00112901
    Ortholog (42)
    Structured_description: Concise_description: rpl-33 encodes a large ribosomal subunit L35a protein. Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit biogenesis. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5 and glioblastoma. Is an ortholog of human RPL35A (ribosomal protein L35a). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3068 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10345)
      DOID:0111883 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10345)
  Molecular_info: Corresponding_CDS: F10E7.7
    Corresponding_transcript: F10E7.7.1
      F10E7.7.2
    Other_sequence (239)
    Associated_feature: WBsf654886
      WBsf657801
      WBsf988353
      WBsf1012485
      WBsf221555
      WBsf221556
  Experimental_info: RNAi_result: WBRNAi00108837 Inferred_automatically: RNAi_primary
      WBRNAi00030775 Inferred_automatically: RNAi_primary
      WBRNAi00108947 Inferred_automatically: RNAi_primary
      WBRNAi00095045 Inferred_automatically: RNAi_primary
      WBRNAi00091074 Inferred_automatically: RNAi_primary
      WBRNAi00109056 Inferred_automatically: RNAi_primary
      WBRNAi00109002 Inferred_automatically: RNAi_primary
      WBRNAi00044262 Inferred_automatically: RNAi_primary
      WBRNAi00008632 Inferred_automatically: RNAi_primary
      WBRNAi00108892 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1015425
      Expr1032251
      Expr1148220
      Expr2015465
      Expr2033700
    Drives_construct: WBCnstr00035479
    Construct_product: WBCnstr00035479
    Regulate_expr_cluster: WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
    Microarray_results (17)
    Expression_cluster: WBPaper00024704:Soluble_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038118:stress_downregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_basal
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045460:pept-1(lg601)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056718:F01D4.5(baf20)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00056997:NMAD-1_interacting
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_downregulated
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059254:WAGO-1_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060871:M.humicola-infection_12h_regulated
      WBPaper00060871:M.humicola-infection_24h_regulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061340:M_cell
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061508:P.mirabilis_36h_upregulated
      WBPaper00061527:rps-5_2365-rpl-15_1655
      WBPaper00061527:rps-14_21270-rps-11_20714
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:ADA_enriched
      WBPaper00061651:CAN_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:Excretory_gland_cell_enriched
      WBPaper00061651:Germline_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:M2_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061651:URX_enriched
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064789:Day6_vs_Day1_downregulated_neuron
      WBPaper00064789:Day9_vs_Day1_downregulated_neuron
      WBPaper00064789:Day12_vs_Day1_downregulated_neuron
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066085:hda-3(ok1991)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      cgc4489_group_3
      WBPaper00005124:cholesterol_10-9M_regulated
      WBPaper00025032:cluster_120
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00042548:miRISC_enriched
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction (198)
  Map_info: Map: II Position: 0.494614 Error: 0.00017
    Positive: Positive_clone: F10E7 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005654
    WBPaper00038491
    WBPaper00049828
    WBPaper00055090
    WBPaper00065861
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene