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WormBase Tree Display for Gene: WBGene00004049

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Name Class

WBGene00004049SMapS_parentSequenceY71F9AL
IdentityVersion2
NameCGC_nameparp-1Person_evidenceWBPerson236
Sequence_nameY71F9AL.18
Molecular_name (13)
Other_namepme-1
CELE_Y71F9AL.18Accession_evidenceNDBBX284601
Public_nameparp-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
218 Nov 2014 11:51:19WBPerson2970Name_changeCGC_nameparp-1
Other_namepme-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classparp
Allele (323)
StrainWBStrain00031749
RNASeq_FPKM (74)
GO_annotation (24)
Ortholog (66)
Paralog (4)
Structured_descriptionConcise_descriptionparp-1 (formerly known as pme-1) encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870); PARP-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain; PARP-1 exhibits poly(ADP-ribose) activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PARP-1 is likely to be required in vivo for repairing broken DNA.Paper_evidenceWBPaper00005600
WBPaper00025222
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated14 Nov 2014 00:00:00
Automated_descriptionEnables NAD+ ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; idiopathic pulmonary fibrosis; and perinatal necrotizing enterocolitis. Is an ortholog of human PARP1 (poly(ADP-ribose) polymerase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9352Homo sapiensPaper_evidenceWBPaper00053647
Curator_confirmedWBPerson324
Date_last_updated04 Mar 2019 00:00:00
Potential_model (14)
Models_disease_assertedWBDOannot00000650
Molecular_infoCorresponding_CDSY71F9AL.18a
Y71F9AL.18b
Y71F9AL.18c
Y71F9AL.18d
Corresponding_transcriptY71F9AL.18a.1
Y71F9AL.18a.2
Y71F9AL.18b.1
Y71F9AL.18c.1
Y71F9AL.18d.1
Other_sequence (12)
Associated_featureWBsf976649
WBsf976650
WBsf983015
WBsf983016
WBsf1009424
WBsf219077
WBsf219078
Experimental_infoRNAi_result (11)
Expr_patternExpr2249
Expr1023238
Expr1031949
Expr1161576
Expr2014736
Expr2032970
Microarray_results (27)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038168:lin-35_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046509:lin-35(n745)_upregulated
WBPaper00048579:aging_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050193:lsm-1(tm3585)_upregulated_L3
WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_enriched_NuGen
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Metformin_downregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056290:hsp-6(mg585)_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058691:WDR-5.1_interacting_protein
WBPaper00059440:LAG-1_interacting_WholeAnimal
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061285:wounding_0h_upregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:C36A4.5_1056-F25D7.4_1055
WBPaper00062056:lin-15B(n744)_upregulated
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062456:doxycycline_downregulated_CB4856_protein
WBPaper00062456:doxycycline_downregulated_N2_protein
WBPaper00062498:PPM-1.D_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064107:lin-52(3A)_vs_lin-52(WT)_upregulated
WBPaper00064505:tamoxifen_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_upregulated_N2
WBPaper00065841:1_2
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_4
cgc4489_group_11
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_D
WBPaper00036286:Pattern_F
WBPaper00038060:SUMO-1_upregulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040426:CYD-1_CDK-4_upregulated
WBPaper00040821:Au-NP_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00056330:mrps-5(RNAi)_downregulated
[cgc6390]:mixed_oogenesis-somatic
Interaction (59)
Map_infoMapIPosition-5.30235Error0.001434
PositivePositive_cloneY71F9ALInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4775
5051
Pseudo_map_position
Reference (24)
RemarkGene information and sequence connection from Serge Desnoyers. krb [020430]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene