| WBGene00004048 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | K04B12 |
| Identity | Version | 1 |
| | Name | CGC_name | plx-2 | Person_evidence | WBPerson644 |
| | | Sequence_name | K04B12.1 |
| | | Molecular_name | K04B12.1 |
| | | | K04B12.1.1 |
| | | | CE53912 |
| | | Other_name | cep-1 | Paper_evidence | WBPaper00018146 |
| | | | | | WBPaper00023469 |
| | | | | | WBPaper00011906 |
| | | | CELE_K04B12.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | plx-2 |
| | DB_info | Database | AceView | gene | 2O704 |
| | | | WormQTL | gene | WBGene00004048 |
| | | | WormFlux | gene | WBGene00004048 |
| | | | NDB | locus_tag | CELE_K04B12.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004048|UniProtKB=O45657 |
| | | | | family | PTHR22625 |
| | | | NCBI | gene | 175101 |
| | | | RefSeq | protein | NM_001377900.1 |
| | | | SwissProt | UniProtAcc | O45657 |
| | | | UniProt_GCRP | UniProtAcc | O45657 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | plx |
| | Allele (139) |
| | Strain | WBStrain00029146 |
| | | WBStrain00029147 |
| | | WBStrain00029148 |
| | | WBStrain00029149 |
| | | WBStrain00030125 |
| | RNASeq_FPKM (74) |
| | GO_annotation (30) |
| | Ortholog (31) |
| | Paralog | WBGene00004047 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | plx-2 encodes one of two C. elegans plexins, conserved transmembrane proteins that function as semaphorin receptors in both vertebrates and invertebrates; plx-2 activity is essential for proper male tail and epidermal morphogenesis and for normal axon guidance in a select group of neurons, including SDQL; genetic analyses indicate that plx-2 functions with mab-20/semaphorin-2a, efn-4/ephrin-4, and unc-129/TGF-beta to regulate male tail morphogenesis and with mab-20 and lad-2/L1CAM to mediate axon guidance; PLX-2 can bind MAB-20 and this interaction is enhanced in the presence of LAD-2; PLX-2::GFP reporters are expressed in a subset of neurons and epidermal cells, as well as a subset (1, 3, 5, and 7) of male sensory ray cell clusters. | Paper_evidence | WBPaper00006490 |
| | | | | | WBPaper00029396 |
| | | | | | WBPaper00031430 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 23 Jul 2008 00:00:00 |
| | | Automated_description | Enables semaphorin receptor activity. Involved in several processes, including axonal fasciculation; nematode larval development; and nematode male tail tip morphogenesis. Located in cell leading edge and cell surface. Expressed in several structures, including P3/4L; P9/10L; P9/10R; neuroblasts; and ray structural cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | K04B12.1 |
| | Corresponding_CDS_history | K04B12.1:wp92 |
| | | K04B12.1:wp109 |
| | | K04B12.1:wp180 |
| | | K04B12.1:wp274 |
| | Corresponding_transcript | K04B12.1.1 |
| | Other_sequence | Dviv_isotig22187 |
| | | FC552303.1 |
| | | ACC17590_1 |
| | | FC551755.1 |
| | | JI164274.1 |
| | | Acan_isotig12889 |
| | | Dviv_isotig33737 |
| | | Dviv_isotig33915 |
| | | Oden_isotig23212 |
| | Associated_feature (17) |
| Experimental_info | RNAi_result | WBRNAi00065915 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00016577 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049879 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000986 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2929 |
| | | Expr4682 |
| | | Expr10005 |
| | | Expr1023808 |
| | | Expr1031948 |
| | | Expr1153584 |
| | | Expr1200099 |
| | | Expr2014968 |
| | | Expr2033203 |
| | Drives_construct (15) |
| | Construct_product (2) |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_4 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057347:nhr-14(tm1473)_downreglated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058648:Y37A1B.5(RNAi)_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:g1A |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:g1A_parent |
| | | WBPaper00061340:g1P |
| | | WBPaper00061340:g2 |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:K_Kprime |
| | | WBPaper00061340:Parents_of_Y_DA6_DA7_DA9 |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:Parent_of_K_Kprime |
| | | WBPaper00061340:pm8 |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:AVJ_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061952:daf-18(nr2037)_upregulated |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062440:crh-1(syb385)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064502:nhr-23(kry61);spe-44(fx110)_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:50_0 |
| | | WBPaper00065841:60_0 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065841:117_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:145_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_23 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (29) |
| | WBProcess | WBbiopr:00000025 |
| Map_info | Map | II | Position | 22.9962 | Error | 0.007199 |
| | Positive | Positive_clone | K04B12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4590 |
| | Pseudo_map_position |
| Reference (148) |
| Remark | Sequence connection from [Takagi S] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| | [wm99ab616], [wm2001p535], and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog |
| Method | Gene |
