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WormBase Tree Display for Gene: WBGene00004014

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Name Class

WBGene00004014SMapS_parentSequenceY37E3
IdentityVersion1
NameCGC_namephb-1Person_evidenceWBPerson364
Sequence_nameY37E3.9
Molecular_nameY37E3.9
Y37E3.9.1
CE26775
Other_nameCELE_Y37E3.9Accession_evidenceNDBBX284601
Public_namephb-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classphb
Allele (26)
RNASeq_FPKM (74)
GO_annotation (19)
Contained_in_operonCEOP1036
Ortholog (37)
ParalogWBGene00004015Caenorhabditis elegansFrom_analysis (2)
Structured_descriptionConcise_descriptionphb-1 encodes the C. elegans ortholog of prohibitin PHB1; loss of phb-1 activity via RNAi indicates that phb-1 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-1, along with prohibitin subunit PHB-2, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products.Paper_evidenceWBPaper00006039
Curator_confirmedWBPerson1843
Date_last_updated20 Dec 2010 00:00:00
Automated_descriptionInvolved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion morphogenesis. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in several structures, including body wall musculature; excretory canal; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate carcinoma in situ; and sporadic breast cancer. Is an ortholog of human PHB1 (prohibitin 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:8991Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8912)
DOID:8634Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8912)
DOID:2671Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8912)
DOID:8029Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8912)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8912)
Molecular_infoCorresponding_CDSY37E3.9
Corresponding_transcriptY37E3.9.1
Other_sequence (132)
Associated_featureWBsf654771
WBsf656007
WBsf980953
WBsf217273
Experimental_infoRNAi_result (121)
Expr_patternExpr8823
Expr1014089
Expr1031921
Expr1159459
Expr2014888
Expr2033123
Drives_constructWBCnstr00013545
Construct_productWBCnstr00013545
Microarray_results (17)
Expression_clusterWBPaper00026640:Development_Group_O
WBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032528:L3_enriched
WBPaper00035073:mitochondria_protein
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00040560:hpl-2_embryo_downregulated
WBPaper00040965:lipid-droplet_associated_protein
WBPaper00041072:UTX-1_interacting_protein
WBPaper00041257:irradiation_upregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044034:LEC-1_associated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_8
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050698:DEP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:OP50_vs_PY79_upregulated_PY79
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056501:P.aeruginosa_upregulated_mitochondria-protein
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:SGP_biased
WBPaper00056900:ERH-2_interacting
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOST-1_interacting
WBPaper00056997:NMAD-1_interacting
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058948:PA14_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_upregulated_protein
WBPaper00059471:EGL-43_interacting
WBPaper00059605:MUT-16_interacting
WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061527:atad-3-mpst-1
WBPaper00061651:Germline_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064201:SNA-3_interacting
WBPaper00064716:paraquat_upregulated
WBPaper00064789:Day9_vs_Day1_downregulated_neuron
WBPaper00064789:Day12_vs_Day1_downregulated_neuron
WBPaper00064841:tent-5(tm3504)_upregulated_protein
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:AFD_depleted
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
WBPaper00025032:cluster_96
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030985:Erwinia_carotovora_upregulated
WBPaper00030985:Serratia_marcesens_upregulated
WBPaper00031003:hlh_1_enriched
WBPaper00032165:differentially_expressed_with_age_medoid_7
WBPaper00032948:FedUp
WBPaper00035479:daf-16(RNAi)_upregulated
WBPaper00036286:Pattern_G
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00039835:ifg-1_upregulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00047070:N2_starvation_downregulated
WBPaper00049538:atfs-1(et18)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
Interaction (139)
Map_infoMapIPosition-11.8948Error0.038996
PositivePositive_cloneY37E3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (16)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene