WormBase Tree Display for Gene: WBGene00004015
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| WBGene00004015 | SMap | S_parent | Sequence | T24H7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | phb-2 | Person_evidence | WBPerson364 | |||||
| Sequence_name | T24H7.1 | ||||||||
| Molecular_name | T24H7.1 | ||||||||
| T24H7.1.1 | |||||||||
| CE40718 | |||||||||
| Other_name | CELE_T24H7.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | phb-2 | ||||||||
| DB_info | Database | AceView | gene | 2G543 | |||||
| WormQTL | gene | WBGene00004015 | |||||||
| WormFlux | gene | WBGene00004015 | |||||||
| NDB | locus_tag | CELE_T24H7.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004015|UniProtKB=P50093 | |||||||
| family | PTHR23222 | ||||||||
| NCBI | gene | 174034 | |||||||
| RefSeq | protein | NM_062849.5 | |||||||
| SwissProt | UniProtAcc | P50093 | |||||||
| TREEFAM | TREEFAM_ID | TF354230 | |||||||
| UniProt_GCRP | UniProtAcc | P50093 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | phb | ||||||||
| Allele (14) | |||||||||
| Strain | WBStrain00002997 | ||||||||
| WBStrain00005595 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00004014 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | phb-2 encodes the C. elegans ortholog of prohibitin PHB2; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-2, along with prohibitin subunit PHB-1, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products. | Paper_evidence | WBPaper00006039 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Dec 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein homodimerization activity. Involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion organization. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in body wall musculature; excretory canal; hypodermis; intestine; and neurons. Is an ortholog of human PHB2 (prohibitin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T24H7.1 | |||||||
| Corresponding_CDS_history | T24H7.1:wp171 | ||||||||
| Corresponding_transcript | T24H7.1.1 | ||||||||
| Other_sequence (133) | |||||||||
| Associated_feature | WBsf654875 | ||||||||
| WBsf657672 | |||||||||
| WBsf981206 | |||||||||
| WBsf988112 | |||||||||
| WBsf221408 | |||||||||
| WBsf221409 | |||||||||
| WBsf221410 | |||||||||
| WBsf221411 | |||||||||
| WBsf221412 | |||||||||
| Experimental_info | RNAi_result (154) | ||||||||
| Expr_pattern | Chronogram1286 | ||||||||
| Expr6760 | |||||||||
| Expr8824 | |||||||||
| Expr1013402 | |||||||||
| Expr1031922 | |||||||||
| Expr1157630 | |||||||||
| Expr2014889 | |||||||||
| Expr2033124 | |||||||||
| Drives_construct | WBCnstr00003500 | ||||||||
| WBCnstr00013546 | |||||||||
| WBCnstr00035740 | |||||||||
| Construct_product | WBCnstr00013546 | ||||||||
| WBCnstr00035740 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (156) | |||||||||
| Interaction (292) | |||||||||
| Map_info | Map | II | Position | -0.394252 | Error | 0.000796 | |||
| Positive | Positive_clone | T24H7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
