WormBase Tree Display for Gene: WBGene00003470

WBGene00003470 SMap: S_parent: Sequence: ZK546
  Identity: Version: 1
    Name: CGC_name: msp-152 Person_evidence: WBPerson680
      Sequence_name: ZK546.6
      Molecular_name: ZK546.6
        ZK546.6.1
        CE02920
      Other_name: CELE_ZK546.6 Accession_evidence: NDB BX284602
      Public_name: msp-152
    DB_info: Database: AceView gene 2F225
        WormQTL gene WBGene00003470
        WormFlux gene WBGene00003470
        NDB locus_tag CELE_ZK546.6
        Panther gene CAEEL|WormBase=WBGene00003470|UniProtKB=Q23519
          family PTHR22920
        NCBI gene 191712
        RefSeq protein NM_062500.10
        SwissProt UniProtAcc Q23519
        UniProt_GCRP UniProtAcc Q23519
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: msp
    Allele: WBVar01499702
      WBVar01498435
      WBVar00728973
      WBVar00728974
      WBVar00728975
      WBVar00365113
      WBVar01783278
      WBVar01783279
    Legacy_information: Cluster of five genes including msp-152 (transcribed).
      [C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of five genes including msp-152 (transcribed). [Ward et al. (1988); BA]
    RNASeq_FPKM (74)
    GO_annotation: 00078717
      00078718
      00078719
      00078720
      00078721
    Ortholog (31)
    Paralog (50)
    Structured_description: Concise_description: msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence: WBPaper00001023
            WBPaper00002143
            WBPaper00003113
            WBPaper00004591
            WBPaper00005670
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 May 2005 00:00:00
      Automated_description: Predicted to be located in cytoplasm; cytoskeleton; and pseudopodium. Expressed in gonad; oocyte; and sperm. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK546.6
    Corresponding_transcript: ZK546.6.1
    Other_sequence (25)
    Associated_feature: WBsf221202
  Experimental_info: RNAi_result (20)
    Expr_pattern: Expr3417
      Expr1162926
      Expr2013771
      Expr2032007
    Drives_construct: WBCnstr00036097
    Construct_product: WBCnstr00036097
    Antibody: WBAntibody00000037
      WBAntibody00000038
      WBAntibody00000854
      WBAntibody00000855
      WBAntibody00000856
      WBAntibody00000857
      WBAntibody00000858
    Microarray_results (8)
    Expression_cluster: WBPaper00029047:atx-3_upregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00041071:spe-44_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00043945:MeHg_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046795:starvation_upregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049266:trx-1(ok1449)_regulated_oxidative-stressed
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_2
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049954:BPA_downregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050231:male_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053657:JU2519_M.humicola-infection_24hr
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054477:cisplatin_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00054996:activated_sperm_CE
      WBPaper00054996:membranous_oraganelle_CE
      WBPaper00054996:unactivated_spermatid_CE
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:ptl-1(ok621)_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:numr-1(RNAi)_upregulated
      WBPaper00057068:numr-1(RNAi)_upregulated_Cadmium
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059426:SiO2-nanoparticles_upregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060744:Radiation_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00060921:tph-1(mg280)_downregulated
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061479:hrde-1(tm1200)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:msp-63-msp-33
      WBPaper00061572:oleic-acid-specific_mating_upregulated
      WBPaper00061651:Sperm_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065578:gcn-1(nc40)_upregulated
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065841:3_3
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066093:E.coli-purE_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4386_cluster_1_1
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026629:L3_male_enriched
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031184:acrylamide_upregulated
      WBPaper00034661:AgNPs_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_0.2mM_Up
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_D
      [cgc6390]:spermatogenesis-enriched
    Interaction (218)
  Map_info: Map: II Position: -2.90252 Error: 0.003087
    Positive: Positive_clone: BA#53
        ZK546 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00001023
    WBPaper00001024
    WBPaper00024312
    WBPaper00025088
    WBPaper00029226
    WBPaper00031218
    WBPaper00040308
    WBPaper00044625
    WBPaper00057218
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene