| WBGene00003153 | SMap | S_parent | Sequence | Y67D8C |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | mca-3 |
| | | Sequence_name | Y67D8C.10 |
| | | Molecular_name (21) |
| | | Other_name | cup-7 | Person_evidence | WBPerson170 |
| | | | CELE_Y67D8C.10 | Accession_evidence | NDB | BX284604 |
| | | Public_name | mca-3 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Acquires_merge | WBGene00000847 |
| | | | | | | | Imported | Initial conversion from geneace |
| | | | 2 | 09 Oct 2007 09:36:44 | WBPerson2970 | Name_change | Other_name | cup-7 |
| | | Acquires_merge | WBGene00000847 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mca |
| | Allele (491) |
| | Legacy_information | [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1. |
| | Strain | WBStrain00032351 |
| | | WBStrain00008044 |
| | | WBStrain00008045 |
| | | WBStrain00007591 |
| | RNASeq_FPKM (74) |
| | GO_annotation (30) |
| | Ortholog (55) |
| | Paralog (14) |
| | Structured_description | Concise_description | mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane. | Paper_evidence | WBPaper00003407 |
| | | | | | WBPaper00004883 |
| | | | | | WBPaper00029172 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 30 Apr 2007 00:00:00 |
| | | Automated_description | Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; nematode larval development; and positive regulation of growth rate. Located in plasma membrane. Expressed in body wall musculature; coelomocyte; intestine; nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814) |
| | | DOID:0111829 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:816) |
| | | DOID:0050564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) |
| | | DOID:0110467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) |
| | | DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) |
| | | DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) |
| Molecular_info | Corresponding_CDS | Y67D8C.10a |
| | | Y67D8C.10b |
| | | Y67D8C.10c |
| | | Y67D8C.10d |
| | | Y67D8C.10e |
| | Corresponding_transcript (11) |
| | Other_sequence (125) |
| | Associated_feature (33) |
| Experimental_info | RNAi_result | WBRNAi00103077 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009413 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00110940 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00057995 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00026914 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00103078 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00103079 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00066558 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00021260 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (8) |
| | Drives_construct | WBCnstr00008391 |
| | Construct_product | WBCnstr00000243 |
| | | WBCnstr00000246 |
| | | WBCnstr00000247 |
| | Microarray_results (52) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038213:E.coli(LF82)_72h_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040412:germline-regulated_daf-16_target |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057254:MWCNT_downregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi) |
| | | WBPaper00060084:DVE-1_interacting_protein_control |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060886:met-2(n4256)_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061527:kin-2_4858-ncx-2_21852 |
| | | WBPaper00061527:npp-8_4368-E01B7.1_7741 |
| | | WBPaper00061527:trcs-2_5724-R11A8.7_17645 |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064735:bet-1B(OE)_vs_N2_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | cgc4489_group_14 |
| | | cgc4489_group_24 |
| | | WBPaper00025032:cluster_179 |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00031850:mdt-15(RNAi)_upregulated |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (38) |
| Map_info | Map | IV | Position | -5.83327 | Error | 0.101838 |
| | Positive | Positive_clone | Y67D8 |
| | | | Y67D8C | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3954 |
| Reference (11) |
| Method | Gene |
