| WBGene00003150 | SMap | S_parent | Sequence | CHROMOSOME_IV |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mbk-2 | Person_evidence | WBPerson1138 |
| | | Sequence_name | F49E11.1 |
| | | Molecular_name (42) |
| | | Other_name | CELE_F49E11.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | mbk-2 |
| | DB_info | Database (14) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mbk |
| | Allele (429) |
| | Strain (30) |
| | RNASeq_FPKM (74) |
| | GO_annotation (67) |
| | Ortholog (42) |
| | Paralog | WBGene00001994 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003149 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00016465 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | WBGene00016464 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | WBGene00006517 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00013727 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00185089 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | mbk-2 encodes one of two C. elegans members of the DYRK (dual-specificity Yak1-related kinase) family of proteins that includes S. cerevisiae Yak1 and the Drosophila minibrain and DYRK2 kinases; MBK-2 activity is required maternally for the oocyte-to-egg transition that occurs during the earliest stages of embryonic development; specifically, MBK-2 is required for: 1) posterior localization of the germ plasm components PIE-1, POS-1, and PGL-1, and 2) post-fertilization degradation of a subset of maternal proteins including the MEI-1 and MEI-2 meiosis-specific katanin subunits, the OMA-1 oocyte maturation factor, and residual PIE-1 that remains anteriorly localized after its normal posterior segregation; MBK-2 also primes the MEX-5 polarity protein for subsequent phosphorylation by the polo-like kinase PLK-1; genetic analyses suggest that, in regulating the segregation and degradation of maternal proteins, MBK-2 lies downstream of the initial embryonic polarity cues established by the PAR and MEX proteins; MBK-2 activity depends upon progression through the meiotic divisions and is positively regulated by CDK-1 and negatively regulated by EGG-3 and EGG-4/5; MBK-2 physically interacts with EGG-3 and EGG-4, suggesting that regulation by EGG-3 and EGG-4 is direct; MBK-2 is expressed uniformly in the cortex of oocytes and newly fertilized zygotes; in later stage zygotes, just prior to the second meiotic division, MBK-2 becomes localized to discrete cortical foci, and by the first mitosis it is found predominantly on centrosomes and chromosomes; MBK-2 is also associated with P granules in the germline blastomeres P2, P3, and P4. | Paper_evidence | WBPaper00006085 |
| | | | | | WBPaper00006352 |
| | | | | | WBPaper00026970 |
| | | | | | WBPaper00026975 |
| | | | | | WBPaper00027607 |
| | | | | | WBPaper00031434 |
| | | | | | WBPaper00035427 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 02 Mar 2011 00:00:00 |
| | | Automated_description | Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including P granule disassembly; asymmetric protein localization involved in cell fate determination; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cell cortex and intracellular non-membrane-bounded organelle. Expressed in several structures, including body wall musculature; embryonic cell; gonad; oocyte; and pharynx. Used to study Down syndrome. Is an ortholog of human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00005756 |
| | | | | Accession_evidence | OMIM | 190685 |
| | | | | | | 614104 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2017 00:00:00 |
| | Disease_relevance | Human DYRK1A gene encodes a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, which includes Drosophila minibrain, and is a conserved gene located in the Down Syndrome critical region (DSCR) of chromosome 21; Down syndrome is the most frequent chromosomal abnormality in human infants, where DYRK1A overexpression is observed, and is characterized by a set of facial and physical features, heart defects, abnormalities in the immune and endocrine systems, spatial memory defecits and difficulty in converting short-term to long-term memories; in elegans, the genes mbk-1 and mbk-2 have close homology with human DYRK1A and hpk-1 is more distantly related; while mutants deficient for mbk-1 seem to be normal, overexpression of mbk-1 causes behavioral defects in chemotaxis, acting in mature, fully differentiated neurons; however, this defect could be reversed by bringing back normal mbk-1 levels, which provided the first hint that DYRK1-induced defects could be reversed; mbk-2(pk1427) homozygous animals display 100% penetrant maternal-effect embryonic lethality, making it difficult to test redundant function with mbk-1. | Homo sapiens | Paper_evidence | WBPaper00005756 |
| | | | | Accession_evidence | OMIM | 600855 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2017 00:00:00 |
| Models_disease_asserted | WBDOannot00000129 |
| Molecular_info | Corresponding_CDS (14) |
| | Corresponding_transcript (14) |
| | Other_sequence (53) |
| | Associated_feature (76) |
| Experimental_info | RNAi_result (38) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00000360 |
| | | WBCnstr00000362 |
| | | WBCnstr00011276 |
| | | WBCnstr00012087 |
| | Construct_product | WBCnstr00000083 |
| | | WBCnstr00000084 |
| | | WBCnstr00000088 |
| | | WBCnstr00000362 |
| | | WBCnstr00000364 |
| | | WBCnstr00010903 |
| | | WBCnstr00011276 |
| | | WBCnstr00011667 |
| | | WBCnstr00012087 |
| | Antibody | WBAntibody00001303 |
| | | WBAntibody00001304 |
| | Microarray_results (61) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033070:Rhine_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_protein |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-extract_1h_regulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:hmc |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:Parent_of_K_Kprime |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:mbk-2_1585-tol-1_22538 |
| | | WBPaper00061527:npp-8_4368-E01B7.1_7741 |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:I1_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:URB_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061902:CAMT-1_interacting |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064315:mes-3(bn199)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_4 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_28 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00027111:rrf-2(ok210)_upregulated |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (272) |
| Map_info | Map | IV | Position | 6.86808 | Error | 0.065322 |
| | Positive | Positive_clone | F49E11 | Inferred_automatically (2) |
| | Mapping_data | Multi_point | 4484 |
| | Pseudo_map_position |
| Reference (64) |
| Remark | Sequence connection from [Raich WB]. 02/06/12 krb. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
