WBGene00002285 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | C05G5 |
| Identity (6) |
| Gene_info (11) |
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00003929 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 25 Oct 2018 00:00:00 |
| | Disease_relevance | let-7 microRNA (miRNA) is highly conserved across species, from C. elegans to humans; there are at least 13 different let-7 family members in humans, C. elegans let-7 being identical to human let-7a; let-7 is generally believed to be a tumor suppressor miRNA, as expression of let-7 family members are down-regulated in many cancers, including lung, breast, ovarian, and prostate cancers, and melanoma, when compared to normal tissues; however upregulation of certain let-7 family members has been observed in a few cancers, indicating that let-7 may not play a tumor suppressor role in all tissues/circumstances; human let-7 targets several cancer-relevant targets for repression including: the RAS/let-60 gene (upregulated in lung cancers), HMGA2, a chromatin-associated non-histone protein, IGF2 mRNA binding protein (IMP1), and lin28B; studies in elegans indicate that let-7 and let-7 miRNA family members and their target genes regulate the expression of the amyloid precursor protein-like, apl-1, (orthologous to human APP), which may provide insights into the progression of Alzheimer''s disease. | Homo sapiens | Paper_evidence | WBPaper00035291 |
| | | | | | WBPaper00031506 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Dec 2013 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000256 |
| Molecular_info | Corresponding_transcript | C05G5.6 |
| | | C05G5.6.1 |
| | | C05G5.6.2 |
| | | C05G5.6.3 |
| | | C05G5.6a |
| | | C05G5.6b |
| | Corresponding_transcript_history | C05G5.6:wp135 |
| | Associated_feature | WBsf718850 |
| | | WBsf979137 |
| | | WBsf1007993 |
| | Gene_product_binds (20) |
| Experimental_info | Expr_pattern (20) |
| | Drives_construct (16) |
| | Construct_product (28) |
| | Regulate_expr_cluster | WBPaper00042165:let-7_downregulated |
| | | WBPaper00042165:let-7_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00050717:let-7(n2853)_lin-41(xe11)_downregulated |
| | | WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated |
| | | WBPaper00064080:let-7_miRNA_interacting |
| | Expression_cluster | WBPaper00028344:adult_expr_change |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040932:lin-28_regulated_microRNA |
| | | WBPaper00042527:age_dependent_miRNA |
| | | WBPaper00045807:microcystin-LR_downregulated_miRNA |
| | | WBPaper00046303:P.aeruginosa_upregulated_miRNA |
| | | WBPaper00048790:12h-starvation_downregulated_miRNA |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050053:muscle_enriched_Day12 |
| | | WBPaper00051404:alg-1(gk214)_upregulated_miRNA |
| | | WBPaper00051404:alg-2(ok304)_upregulated_miRNA |
| | | WBPaper00051404:alg-5(ram2)_downregulated_miRNA |
| | | WBPaper00051404:alg-5(tm1163)_upregulated_miRNA |
| | | WBPaper00053318:Aging_downregulated_miRNA_mir-71(n4115) |
| | | WBPaper00053318:Aging_downregulated_miRNA_N2 |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00054410:set-9(rw5)_downregulated |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055013:hmg-3(bar24)_downregulated |
| | | WBPaper00055013:spt-16(RNAi)_downregulated |
| | | WBPaper00055663:sanguinarine_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056290:mdt-15(mg584)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057033:pry-1(mu38)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA |
| | | WBPaper00058673:hrpk-1(tm5522)_downregulated_miRNA_L4 |
| | | WBPaper00060100:SiNP_upregulated_miRNA |
| | | WBPaper00060445:ikb-1(nr2027)_downregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00064788:ketamine_upregulated |
| | Interaction (449) |
| | WBProcess | WBbiopr:00000020 |
| | | WBbiopr:00000057 |
| | | WBbiopr:00000081 |
| | | WBbiopr:00000083 |
| Map_info | Map | X | Position | 21.2192 | Error | 0.067046 |
| | Well_ordered |
| | Positive | Positive_clone | C05G5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 192 |
| | | Multi_point | 188 |
| | | | 4742 |
| | | Pos_neg_data | 2068 |
| | | | 2096 |
| | | | 2200 |
| | | | 2205 |
| | | | 2212 |
| | | | 2218 |
| | | | 2224 |
| | | | 2275 |
| | | | 2279 |
| Reference (475) |
| Remark | Sequence connection from [Reinhart BJ, Slack FJ] |
| | Rfam accession number: MI0000001 |
| Method | Gene |