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WormBase Tree Display for Gene: WBGene00002241

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Name Class

WBGene00002241SMapS_parentSequenceF10C2
IdentityVersion1
NameCGC_namekup-1Person_evidenceWBPerson71
Sequence_nameF10C2.2
Molecular_nameF10C2.2
F10C2.2.1
CE09306
Other_namekup1Accession_evidenceEMBLL12247
CELE_F10C2.2Accession_evidenceNDBBX284605
Public_namekup-1
DB_infoDatabaseAceViewgene5M514
WormQTLgeneWBGene00002241
WormFluxgeneWBGene00002241
NDBlocus_tagCELE_F10C2.2
NCBIgene179651
RefSeqproteinNM_001392622.1
SwissProtUniProtAccP34705
UniProt_GCRPUniProtAccP34705
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classkup
Allele (99)
Legacy_information[C.elegansII] NMK. Upstream in operon with kin-13. Encodes predicted 385 aa novel protein. Antibody stains nuclei of most cells. [Zorio et al. 1994; CR]
StrainWBStrain00035751
RNASeq_FPKM (74)
Contained_in_operonCEOP5312
Ortholog (27)
Structured_descriptionConcise_descriptionkup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known.Paper_evidenceWBPaper00001950
WBPaper00005493
WBPaper00005654
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnriched in several structures, including AVK; MSaapaapa; accessory cell; anterior arcade cell; and g2 based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including daf-16; glp-1; and gld-1 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by thirteen chemicals including rotenone; mianserin; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Phosphorylation site.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF10C2.2
Corresponding_transcriptF10C2.2.1
Other_sequence (42)
Associated_feature (30)
Experimental_infoRNAi_resultWBRNAi00044221Inferred_automaticallyRNAi_primary
WBRNAi00013038Inferred_automaticallyRNAi_primary
WBRNAi00085043Inferred_automaticallyRNAi_primary
Expr_patternExpr12857
Expr1021564
Expr1031316
Expr1148182
Expr2012983
Expr2031215
Drives_constructWBCnstr00022908
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032031:DConiospora_upregulated_cDNA_24h
WBPaper00032097:CGH-1-associated-mRNA
WBPaper00032425:up_in_lin-35
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-35_upregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00046509:lin-35(n745)_upregulated
WBPaper00048762:FOG-3_associated
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050686:glp-1(e2141)_downregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00054792:FOG-3_interacting
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056826:SGP_biased
WBPaper00057288:Cold_upregulated_transcript
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00059763:neuron_expressed
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061106:endu-2(tm4977)_downregulated
WBPaper00061340:ADA_ADE_grandparent
WBPaper00061340:ADEsh
WBPaper00061340:Anterior_arcade_cell
WBPaper00061340:CEPso
WBPaper00061340:g1A_parent
WBPaper00061340:g2
WBPaper00061340:Glia
WBPaper00061340:ILsh_OLLsh_OLQsh
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:F54E7.8-orc-5_6376
WBPaper00061527:T02E1.2-uri-1
WBPaper00062056:dpl-1(n2994)_upregulated
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062056:lin-36(we31)_upregulated
WBPaper00062056:lin-36(we36)_upregulated
WBPaper00062056:lin-37(n758)_upregulated
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_2
WBPaper00005124:testosterone_10-9M_regulated
WBPaper00025032:cluster_176
WBPaper00025032:PAL-1_target_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00035905:FBF-1_Associated
WBPaper00036130:mir-243_down_regulated
WBPaper00036286:Pattern_B
WBPaper00037611:GLD-2-associated
WBPaper00037611:RNP-8-associated
WBPaper00037695:LD_3-day
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00038427:lin-54_embryo_changed
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040426:CYD-1_CDK-4_upregulated
WBPaper00040426:CYE-1_CDK-2AF_upregulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040963:TA300_down
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
[cgc5767]:cluster_24
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(83_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MD_pd(23_min)
[cgc5767]:expression_class_ME
[cgc6390]:oogenesis-enriched
InteractionWBInteraction000227835
WBInteraction000396019
WBInteraction000435475
WBInteraction000574965
WBInteraction000576308
Map_infoMapVPosition3.60848Error0.003861
PositivePositive_cloneF10C2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point (2)
Pseudo_map_position
ReferenceWBPaper00001723
WBPaper00002006
WBPaper00005493
WBPaper00010944
WBPaper00015440
WBPaper00022096
WBPaper00031335
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene