WormBase Tree Display for Gene: WBGene00002020

WBGene00002020 SMap: S_parent: Sequence: T27E4
  Identity: Version: 1
    Name: CGC_name: hsp-16.49 Person_evidence: WBPerson36
      Sequence_name: T27E4.9
      Molecular_name: T27E4.9
        T27E4.9.1
        CE14251
      Other_name: hsp-16
        CELE_T27E4.9 Accession_evidence: NDB BX284605
      Public_name: hsp-16.49
    DB_info: Database: AceView gene 5J570
        WormFlux gene WBGene00002020
        NDB locus_tag CELE_T27E4.9
        NCBI gene 179288
        RefSeq protein NM_072955.3
        SwissProt UniProtAcc P02513
        UniProt_GCRP UniProtAcc P02513
        OMIM gene 123580
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsp
    Allele: WBVar01499903
      WBVar01500129
      WBVar01499419
      WBVar01499420
      WBVar01499056
      WBVar01499249
      WBVar00250229
      WBVar01499316
    In_cluster: HSP16A
    RNASeq_FPKM (74)
    GO_annotation: 00105708
      00105759
      00106140
    Ortholog (88)
    Paralog (17)
    Structured_description: Concise_description: hsp-16.49 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.48; HSP-16.49 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. Paper_evidence: WBPaper00004424
            WBPaper00013029
            WBPaper00013239
            WBPaper00013280
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110266 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2388)
  Molecular_info: Corresponding_CDS: T27E4.9
    Corresponding_transcript: T27E4.9.1
    Other_sequence (109)
    Associated_feature: WBsf234179
  Experimental_info: RNAi_result: WBRNAi00093732 Inferred_automatically: RNAi_primary
      WBRNAi00063167 Inferred_automatically: RNAi_primary
      WBRNAi00106385 Inferred_automatically: RNAi_primary
      WBRNAi00106384 Inferred_automatically: RNAi_primary
    Expr_pattern (3)
    Drives_construct: WBCnstr00010087
      WBCnstr00036516
    Construct_product: WBCnstr00036516
    Antibody: WBAntibody00001859
    Microarray_results: SMD_T27E4.9
      Aff_T27E4.3
    Expression_cluster: WBPaper00005432:xbp-1(zc12)_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00036291:ung-1_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00038061:aldicarb_downregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040135:heat-shock_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040529:TWE_regulated
      WBPaper00040731:Static_Magnetic_Field_upregulated
      WBPaper00042034:NO_upregulated_N2
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Gender_Neutral
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049098:heat-induced_hrde-1(tm1200)
      WBPaper00049098:heat-induced_N2
      WBPaper00049266:NaAsO2-Stress_regulated_N2
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059440:LAG-1_interacting_germline
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059605:simr-1(cmp36)_downregulated
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062345:bortezomib_30min_upregulated_N2
      WBPaper00062345:bortezomib_30min_upregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064130:Beta-Amyloid_8h_upregulated_mRNA
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064201:SNA-3_interacting
      WBPaper00064225:heat-shock_upregulated_protein
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064789:Day3_vs_Day1_downregulated_neuron
      WBPaper00064789:Day6_vs_Day1_downregulated_neuron
      WBPaper00064789:Day9_vs_Day1_downregulated_neuron
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064952:Day1_vs_L4_downregulated_20C
      WBPaper00064952:Day10_vs_Day1_upregulated_20C
      WBPaper00064952:Day10_vs_Day1_upregulated_25C
      WBPaper00064952:Day10_vs_Day5_upregulated_25C
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00066038:mip-1(how5)_downregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_4_5
      cgc4489_group_8
      WBPaper00006465:I_ethanol_rapid_induction
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027758:Group_III
      WBPaper00028948:cep-1(gk138)_upregulated
      WBPaper00031184:acrylamide_upregulated
      WBPaper00031662:spaceflight_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      [cgc5767]:cluster_52
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SET
      [cgc5767]:expression_class_SE_pi(53_min)
      [cgc6390]:Cluster_C
    Interaction (28)
  Map_info: Map: V Position: 1.9262 Error: 0.001695
    Positive: Positive_clone: T27E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4419
    Pseudo_map_position
  Reference (61)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene