WormBase Tree Display for Gene: WBGene00001840

WBGene00001840 SMap: S_parent: Sequence: C26D10
  Identity: Version: 1
    Name: CGC_name: hel-1
      Sequence_name: C26D10.2
      Molecular_name: C26D10.2a
        C26D10.2a.1
        CE03025
        C26D10.2b
      Other_name: hel Accession_evidence: EMBL U08102
        CELE_C26D10.2 Accession_evidence: NDB BX284602
      Public_name: hel-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hel
    Allele (30)
    Strain: WBStrain00001557
      WBStrain00002229
      WBStrain00035692
      WBStrain00037647
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (40)
    Paralog (37)
    Structured_description: Concise_description: hel-1 encodes an ortholog of human 56-kD U2AF65 associated protein (UAP56)that is required for exporting mRNAs from the nucleus; unlike animals withRNAi against several other splicing factors, hel-1(RNAi) animals fail toexport transgenic GFP mRNA from the nucleus; conversely, hel-1overexpression is lethal, with failed transgene expression as well. Paper_evidence: WBPaper00005959
          Curator_confirmed: WBPerson567
          Date_last_updated: 06 Sep 2006 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; nuclear mRNA surveillance; and positive regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is an ortholog of human DDX39A (DExD-box helicase 39A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13917)
  Molecular_info: Corresponding_CDS: C26D10.2a
    Corresponding_CDS_history: C26D10.2:wp92
      C26D10.2:wp96
      C26D10.2b:wp96
      C26D10.2b:wp250
    Corresponding_transcript: C26D10.2b
      C26D10.2a.1
    Other_sequence (241)
    Associated_feature (8)
  Experimental_info: RNAi_result (38)
    Expr_pattern: Chronogram952
      Expr5341
      Expr5342
      Expr12409
      Expr1026321
      Expr1031084
      Expr1145299
      Expr2012395
      Expr2030631
    Drives_construct: WBCnstr00002397
      WBCnstr00004329
      WBCnstr00020985
    Construct_product: WBCnstr00020985
    Antibody: WBAntibody00000651
    Microarray_results (24)
    Expression_cluster: WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1291
      WBPaper00029359_1546
      WBPaper00030894:daf-2(e1370ts)_downregulated
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_rde-4
      WBPaper00032528:L3_enriched
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044128:daf-2(e1370)_downregulated
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_Day10
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050599:nicotine(1mM)_upregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_nucleus_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00061340:ASI_parent
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:AFFX-r2-3487-3_s_at-tba-1
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061651:Germline_enriched
      WBPaper00062002:Day4-adult_secretome
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064201:SNA-3_interacting
      WBPaper00064624:iHg-induced_aggregome
      WBPaper00064716:paraquat_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_2
      cgc4489_group_3
      WBPaper00025032:cluster_22
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00035905:FBF-1_Associated
      WBPaper00037695:DD_3-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:oogenesis-enriched
    Interaction (249)
  Map_info: Map: II Position: 0.761021 Error: 0.000763
    Positive: Positive_clone: C26D10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4399
        4274
        4548
    Pseudo_map_position
  Reference (11)
  Remark: Pseudogene tag removed because the corresponding sequence object for this gene has not been annotated as a pseudogene. This discrepancy may reflect that the sequence object was once a pseudogene and has subsequently been converted into a real gene (without this Locus object being updated). Alternatively it may be that this gene is a pseudogene in another C. elegans strain, but not in the sequenced N2 strain. [krb 030806]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene