WormBase Tree Display for Gene: WBGene00001831

WBGene00001831 SMap: S_parent: Sequence: F58A4
  Identity: Version: 1
    Name: CGC_name: hcp-3 Person_evidence: WBPerson537
      Sequence_name: F58A4.3
      Molecular_name: F58A4.3
        F58A4.3.1
        CE00219
      Other_name: CeCENP-A Paper_evidence: WBPaper00026659
        CENP-A Paper_evidence: WBPaper00053817
        CELE_F58A4.3 Accession_evidence: NDB BX284603
      Public_name: hcp-3
    DB_info: Database: AceView gene 3K704
        WormQTL gene WBGene00001831
        WormFlux gene WBGene00001831
        NDB locus_tag CELE_F58A4.3
        Panther gene CAEEL|WormBase=WBGene00001831|UniProtKB=P34470
          family PTHR11426
        NCBI gene 176359
        RefSeq protein NM_066727.7
        SwissProt UniProtAcc P34470
        TREEFAM TREEFAM_ID TF352440
        UniProt_GCRP UniProtAcc P34470
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hcp
    Allele (12)
    Strain: WBStrain00036564
      WBStrain00034729
    RNASeq_FPKM (74)
    GO_annotation (35)
    Ortholog (36)
    Paralog (24)
    Structured_description: Concise_description: The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. Paper_evidence: WBPaper00003702
            WBPaper00004736
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 Dec 2005 00:00:00
      Automated_description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in several processes, including negative regulation of mitotic centrosome separation; non-membrane-bounded organelle assembly; and protein localization to chromosome. Located in kinetochore and nucleus. Expressed in embryonic cell; hyp3; hyp4; hyp7 syncytium; and seam cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F58A4.3
    Corresponding_transcript: F58A4.3.1
    Other_sequence: CBC08194
    Associated_feature: WBsf651390
      WBsf993732
      WBsf227335
  Experimental_info: RNAi_result (32)
    Expr_pattern (11)
    Drives_construct: WBCnstr00014536
      WBCnstr00022767
      WBCnstr00022768
      WBCnstr00036660
    Construct_product: WBCnstr00014534
      WBCnstr00014535
      WBCnstr00014536
      WBCnstr00022767
      WBCnstr00036660
    Antibody: WBAntibody00000241
      WBAntibody00000379
      WBAntibody00000811
      WBAntibody00000812
      WBAntibody00001030
      WBAntibody00002323
      WBAntibody00002956
    Microarray_results (17)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00037946:MAB-5_interacting
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041071:spe-44_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_protein
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048762:FOG-1_associated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_downregulated_smallRNA
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:AMso_parent
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:Parent_of_hyp3_ILsoDx
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:RIM_parent
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_2
      cgc4489_group_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037695:DD_3-day
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (233)
  Map_info: Map: III Position: 0.752765 Error: 0.006625
    Positive: Positive_clone: F58A4 Inferred_automatically (2)
    Pseudo_map_position
  Reference (42)
  Remark: Sequence connection from [Moore LL, Roth MB]. krb 13/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene