| WBGene00001368 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F35H8 |
| Identity | Version | 2 |
| | Name (5) |
| | DB_info | Database | AceView | gene | 2J871 |
| | | | WormQTL | gene | WBGene00001368 |
| | | | WormFlux | gene | WBGene00001368 |
| | | | NDB | locus_tag | CELE_F35H8.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001368|UniProtKB=Q20084 |
| | | | | family | PTHR24012 |
| | | | NCBI | gene | 174506 |
| | | | RefSeq | protein | NR_175828.1 |
| | | | | | NM_063656.6 |
| | | | TrEMBL | UniProtAcc | Q20084 |
| | | | UniProt_GCRP | UniProtAcc | Q20084 |
| | | | RNAcentral | URSid | URS000242F08E |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 09 Nov 2004 13:58:18 | WBPerson2970 | Name_change | Other_name | cel-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | exc |
| | Allele (88) |
| | Legacy_information | [Buechner M] exc for excretory canal defect. Canal is invariably short with multiple cysts of varying size clustered along length, especially at the tips. Visible only by Nomarski microscopy. Animal is somewhat pale. |
| | | [C.elegansII] rh252 : excretory canal defect. Canal is invariably short with multiple cysts of varying size clustered along length, especially at the tips. Visible only by Nomarski microscopy. Animal is somewhat pale. NA1. [NJ] |
| | Strain | WBStrain00002848 |
| | | WBStrain00028852 |
| | | WBStrain00035561 |
| | | WBStrain00047414 |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (55) |
| | Paralog (15) |
| | Structured_description | Concise_description | exc-7 encodes an ELAV, an mRNA-binding protein homologous to Drosophila ELAV and human HuC/D (OMIM:603458, 168360, autoimmune antigens associated with paraneoplastic neurologic disorders); EXC-7 is required for formation of the tailspike and the excretory cell canals; exc-7 mutations enhance defects produced by mutations in exc-3, predicted to encode a peptidase, and sma-1, which encodes beta H-spectrin, a key component of the apical cytokeleton of polarized epithelial cells such as the excretory cell; in vitro, EXC-7 can bind the sma-1 mRNA 3' UTR, and thus is predicted to regulate SMA-1 expression in vivo; EXC-7 is expressed transiently in the excretory cell nucleus during mid-embryogenesis and during larval stages is detected in the pharynx, nerve ring, and nerve cord nuclei. | Paper_evidence | WBPaper00003721 |
| | | | | | WBPaper00005833 |
| | | | | | WBPaper00006029 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 02 Mar 2009 00:00:00 |
| | | Automated_description | Enables single-stranded RNA binding activity. Involved in several processes, including epithelial cell development; regulation of alternative mRNA splicing, via spliceosome; and regulation of neuron differentiation. Located in nuclear speck. Expressed in several structures, including excretory cell; neurons; somatic nervous system; tail; and vulva. Is an ortholog of human ELAVL4 (ELAV like RNA binding protein 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F35H8.5a |
| | Corresponding_transcript | F35H8.5b |
| | | F35H8.5a.1 |
| | Other_sequence (31) |
| | Associated_feature (22) |
| Experimental_info | RNAi_result | WBRNAi00087534 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080076 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00046434 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080160 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00014387 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00031822 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00003370 |
| | | WBCnstr00010161 |
| | | WBCnstr00010162 |
| | | WBCnstr00010851 |
| | | WBCnstr00010895 |
| | | WBCnstr00036987 |
| | Construct_product | WBCnstr00010161 |
| | | WBCnstr00010162 |
| | | WBCnstr00010895 |
| | | WBCnstr00036987 |
| | Regulate_expr_cluster | WBPaper00051540:exc-7(csb29);mbl-1(csb30)_downregulated |
| | | WBPaper00051540:exc-7(csb29);mbl-1(csb30)_upregulated |
| | | WBPaper00051540:exc-7(csb29)_downregulated |
| | | WBPaper00051540:exc-7(csb29)_upregulated |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00029359_1271 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040209:B.thuringiensis_upregulated_MY18 |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_enriched |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:epidermis_specific |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:CEP |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:Excretory_gland |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:g1A_parent |
| | | WBPaper00061340:g2 |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:MC |
| | | WBPaper00061340:Neuroblast_AVG_RIR |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:Pharyngeal_neuron |
| | | WBPaper00061340:pm1_pm2 |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RME |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:kin-2_4858-ncx-2_21852 |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:I1_enriched |
| | | WBPaper00061651:M1_enriched |
| | | WBPaper00061651:M3_enriched |
| | | WBPaper00061651:M5_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:MI_enriched |
| | | WBPaper00061651:RIC_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061651:VC_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:58_1 |
| | | WBPaper00065841:59_0 |
| | | WBPaper00065841:96_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_23 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027111:rde-3(r459)_upregulated |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (108) |
| Map_info | Map | II | Position | 1.60952 | Error | 0.004466 |
| | Well_ordered |
| | Positive | Positive_clone | E02H1 |
| | | | F35H8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 7027 |
| | | Multi_point | 3292 |
| | | | 4488 |
| | | | 4753 |
| | | Pos_neg_data | 8597 |
| | | | 8598 |
| | | | 8599 |
| | | | 8600 |
| | | | 8601 |
| | | | 8602 |
| | | | 8603 |
| | | | 8604 |
| | | | 8605 |
| Reference (42) |
| Method | Gene |
