WormBase Tree Display for Gene: WBGene00000960

WBGene00000960 SMap: S_parent: Sequence: F54G8
  Identity: Version: 1
    Name: CGC_name: dgk-3 Person_evidence: WBPerson453
      Sequence_name: F54G8.2
      Molecular_name: F54G8.2
        F54G8.2.1
        CE46230
      Other_name: CELE_F54G8.2 Accession_evidence: NDB BX284603
      Public_name: dgk-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dgk
    Allele (60)
    Strain: WBStrain00035591
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (43)
    Paralog: WBGene00000958 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000959 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006483 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019428 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: dgk-3 encodes a diacylglycerol kinase that is the C. elegans ortholog of mammalian DGK-beta; dgk-3 activity is required for regulation of long-term thermotactic behavioral plasticity and for regulation of olfactory adaptation; large-scale expression studies have reported dgk-3 expression in head neurons, the intestine, and the pharyngeal lumen, while expression profiling indicates that dgk-3 is expressed in the AFD thermosensory neurons as well as a small number of additional sensory neurons. Paper_evidence: WBPaper00002318
            WBPaper00006525
            WBPaper00024671
            WBPaper00027044
            WBPaper00028767
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Feb 2007 00:00:00
      Automated_description: Predicted to enable ATP-dependent diacylglycerol kinase activity. Involved in olfactory behavior; regulation of long-term neuronal synaptic plasticity; and thermotaxis. Predicted to be located in plasma membrane. Expressed in amphid neurons; head; and pharyngeal lumen. Is an ortholog of human DGKA (diacylglycerol kinase alpha); DGKB (diacylglycerol kinase beta); and DGKG (diacylglycerol kinase gamma). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F54G8.2
    Corresponding_CDS_history: F54G8.2:wp98
      F54G8.2:wp227
    Corresponding_transcript: F54G8.2.1
    Other_sequence (14)
    Associated_feature: WBsf645468
      WBsf993593
      WBsf993594
      WBsf993595
      WBsf1015556
  Experimental_info: RNAi_result: WBRNAi00048388 Inferred_automatically: RNAi_primary
      WBRNAi00006163 Inferred_automatically: RNAi_primary
      WBRNAi00015668 Inferred_automatically: RNAi_primary
      WBRNAi00032822 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram293
      Expr23
      Expr6186
      Expr11097
      Expr1022527
      Expr1152180
      Expr2010865
      Expr2029103
    Drives_construct: WBCnstr00002601
      WBCnstr00018166
      WBCnstr00037178
    Construct_product: WBCnstr00018166
      WBCnstr00037178
    Microarray_results (22)
    Expression_cluster: WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:AFD
      WBPaper00061340:AIY
      WBPaper00061340:ASE
      WBPaper00061340:AWB
      WBPaper00061340:AWC
      WBPaper00061340:BAG
      WBPaper00061340:RIH
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:ckr-1-T09B9.3
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:35_0
      WBPaper00065841:35_1
      WBPaper00065841:35_2
      WBPaper00065841:35_3
      WBPaper00065841:39_3
      WBPaper00065841:59_0
      WBPaper00065841:90_0
      WBPaper00065841:96_0
      WBPaper00065841:111_0
      WBPaper00065841:142_0
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_15
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00024671:AFD_vs_AWB_upregulated
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
    Interaction: WBInteraction000009141
      WBInteraction000049966
      WBInteraction000122632
      WBInteraction000173106
      WBInteraction000382709
      WBInteraction000411402
      WBInteraction000419419
      WBInteraction000439799
      WBInteraction000456311
  Map_info: Map: III Position: 0.250771 Error: 0.010231
    Positive: Positive_clone: F54G8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4257
        4516
    Pseudo_map_position
  Reference (16)
  Remark (2)
  Method: Gene