WormBase Tree Display for Gene: WBGene00000796

WBGene00000796 Evidence: Paper_evidence: WBPaper00005857
  SMap: S_parent: Sequence: C14A4
  Identity: Version: 2
    Name: CGC_name: crn-3 Person_evidence: WBPerson1606
      Sequence_name: C14A4.4
      Molecular_name: C14A4.4a
        C14A4.4a.1
        CE02145
        C14A4.4b
        CE51406
        C14A4.4b.1
      Other_name: exos-10 Person_evidence: WBPerson699
            WBPerson6229
        CELE_C14A4.4 Accession_evidence: NDB BX284602
      Public_name: crn-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Jun 2007 15:54:19 WBPerson2970 Name_change: Other_name: exos-10
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: crn
    Allele (78)
    Strain: WBStrain00036816
      WBStrain00007421
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP2496
    Ortholog (39)
    Paralog: WBGene00013256 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015680 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. Paper_evidence: WBPaper00004424
            WBPaper00005857
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be located in nucleolus. Predicted to be part of nuclear exosome (RNase complex). Is an ortholog of human EXOSC10 (exosome component 10). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C14A4.4a
      C14A4.4b
    Corresponding_CDS_history: C14A4.4b:wp252
    Corresponding_transcript: C14A4.4a.1
      C14A4.4b.1
    Other_sequence (17)
    Associated_feature: WBsf658150
      WBsf222034
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr16396
      Expr1026985
      Expr1030495
      Expr1144539
      Expr2010538
      Expr2028778
    Drives_construct: WBCnstr00037270
      WBCnstr00042997
    Construct_product: WBCnstr00037270
      WBCnstr00042997
    Microarray_results (29)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_embryo_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049290:rsks-1(sv31)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049954:BPS_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050743:elli-1(sam-3)_upregulated
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00054571:BPA_F3_germline_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:mtr-4_1623-W03F9.10_103
      WBPaper00061527:Y32B12B.2-F28C1.1
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062590:Aging_upregulated_hypodermis
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_1
      cgc4489_group_2
      WBPaper00025032:cluster_15
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00036130:mir-243_down_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(66_min)
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:oogenesis-enriched
    SAGE_tag (15)
    Interaction (224)
    WBProcess (2)
  Map_info: Map: II Position: 3.11949 Error: 0.000279
    Positive: Positive_clone: C14A4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005857
    WBPaper00006283
    WBPaper00019408
    WBPaper00027291
    WBPaper00038491
    WBPaper00048226
    WBPaper00055090
    WBPaper00057242
    WBPaper00065012
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene