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WormBase Tree Display for Gene: WBGene00000788

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Name Class

WBGene00000788EvidencePaper_evidenceWBPaper00004821
SMapS_parentSequenceF32B5
IdentityVersion1
NameCGC_namecpz-1
Sequence_nameF32B5.8
Molecular_nameF32B5.8a
F32B5.8a.1
CE36646
F32B5.8b
CE50019
F32B5.8b.1
Other_nameCELE_F32B5.8Accession_evidenceNDBBX284601
Public_namecpz-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcpz
Allele (65)
StrainWBStrain00031453
RNASeq_FPKM (74)
GO_annotation (19)
Ortholog (34)
Paralog (28)
Structured_descriptionConcise_descriptioncpz-1 encodes a homolog of cathepsin z-like cysteine protease cyclicallyexpressed in hypodermal cells throughout development (along with adultgonad and pharynx) and required for normal molting; CPZ-1 protein ispresent in cuticle regions shortly before their degradation duringecydsis, and this expression pattern is conserved in Onchocerca volvulus;cpz-1(ok497) and cpz-1(RNAi) worms have defective molting, along withmisshapen heads and tails, defective gonads, and embryonic lethality.Paper_evidenceWBPaper00006379
Curator_confirmedWBPerson567
Date_last_updated21 Aug 2006 00:00:00
Automated_descriptionPredicted to enable cysteine-type endopeptidase activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; gonad morphogenesis; and post-embryonic development. Located in collagen and cuticulin-based cuticle extracellular matrix; extracellular space; and yolk granule. Expressed in several structures, including anterior hypodermis; cuticle; intestine; pharynx; and vulva. Is an ortholog of human CTSZ (cathepsin Z).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF32B5.8a
F32B5.8b
Corresponding_CDS_historyF32B5.8:wp123
Corresponding_transcriptF32B5.8a.1
F32B5.8b.1
Other_sequence (237)
Associated_featureWBsf648984
WBsf717464
WBsf980972
WBsf982941
WBsf1009378
WBsf219056
Experimental_infoRNAi_result (12)
Expr_patternExpr2400
Expr2892
Expr2893
Expr7868
Expr1014352
Expr1030489
Expr1149993
Expr2010522
Expr2028762
Drives_constructWBCnstr00010810
WBCnstr00011010
WBCnstr00019867
WBCnstr00037275
Construct_productWBCnstr00037275
AntibodyWBAntibody00000710
Microarray_results (18)
Expression_clusterWBPaper00005700:transmembrane_protein
WBPaper00027057:DCR-1_interacting_adult
WBPaper00028802:intestine_unique
WBPaper00030922:glycosylated_protein
WBPaper00032425:down_in_zfp-1
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035269:cde-1_regulated
WBPaper00037849:sam-10(js94)_upregulated
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_embryo_enriched
WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
WBPaper00044037:eat-2_downregulated
WBPaper00044128:daf-2(e1370)_downregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045303:ZK1236.1(tm4178)_upregulated
WBPaper00045420:fertilization_downregulated_protein
WBPaper00045521:Gender_Neutral
WBPaper00046121:endoderm_unique
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048530:fshr-1(ok778)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050698:DEP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F4_morc-1(tm6048)_downregulated
WBPaper00051305:vit-2(ac3)_downregulated
WBPaper00051352:Long-Term-Association-Memory_downregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051404:alg-2(ok304)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053402:cco-1(RNAi)_downregulated
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053615:SMO-1_target
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053792:Ochrobactrum_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00054872:egl-9(sa307)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055827:daf-2(e1370)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056161:male_enriched_siRNA
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay1
WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay4
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059027:neuron-synapses_enriched
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059334:SACY-1_interacting
WBPaper00059373:stt-3(RNAi)_downregulated
WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_upregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059605:MUT-16_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_downregulated_adult
WBPaper00059739:hira-1(gk835598)_downregulated_L1
WBPaper00059739:hira-1(gk835598)_downregulated_L4
WBPaper00059763:neuron_expressed
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059839:S.maltophilia_regulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060951:mrpl-2(osa3)_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061340:Intestine
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
WBPaper00061466:nath-10(icb102)_downregulated
WBPaper00061527:R10H10.3-T21H3.1
WBPaper00061651:Intestine_enriched
WBPaper00061818:ELKS-1_interacting
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062440:crh-1(n3315)_upregulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064005:starvation_upregulated_N2_protein
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064163:ZNFX-1_interacting_embryo
WBPaper00064201:SNA-3_interacting
WBPaper00064539:nhr-114(gk849)_downregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065199:Transgeneration-starvation_regulated_fed
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065392:Lb.delbrueckii_downregulated
WBPaper00065392:Lb.plantarum_downregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_5
WBPaper00065841:4_0
WBPaper00065841:4_1
WBPaper00065841:18_0
WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_upregulated
cgc4386_cluster_1_2
cgc4489_group_20
WBPaper00025032:cluster_37
WBPaper00025141:N2_Expressed_Genes
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032165:differentially_expressed_with_age_medoid_6
WBPaper00032948:FedUp
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036286:Pattern_I
WBPaper00038172:crh-1null_down_regulated
WBPaper00038304:octr-1_regulated
WBPaper00039866:ClassComp_daf-19_upregulated
WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00040963:TA200_down
WBPaper00040963:TA300_down
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042236:flcn-1(ok975)_upregulated
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00046548:dafachronic-acid_upregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
[cgc5767]:cluster_12
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(122_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:mixed_spermatogenesis-somatic
Interaction (23)
Map_info (4)
ReferenceWBPaper00006379
WBPaper00010400
WBPaper00027761
WBPaper00038491
WBPaper00055090
WBPaper00059755
WBPaper00062444
WBPaper00064339
WBPaper00065026
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
Homolog of Ov-cpz-1Paper_evidenceWBPaper00004821
MethodGene